A Phase 4 interventional study of Desflurane and Propofol in Thoracic Surgery, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-02-17.
Sponsored by University of Zurich · Phase 4, Interventional, and Treatment
Desflurane and its effect on postoperative morbidity and mortality in patients undergoing thoracic surgery.
Halothane, enflurane, isoflurane, sevoflurane, and desflurane are volatile anesthetics, a group of general anesthetics. Because of the hypnotic effects of these agents, attention has mainly focused on the central nervous system. In the last 10 years, however, numerous studies have reported that volatile anesthetic agents interact with membrane structures of the myocardium and thereby attenuate cardiac mechanical dysfunction and limit ultrastructural abnormality on reperfusion after prolonged ischemia in the myocyte. Anesthetic-induced preconditioning has become a main topic in cardiac research worldwide
University of Zurich is the lead sponsor of 1,048 studies on the registry; 131 are open to participants now.
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Inclusion criteria: • Elective thoracic surgery (thoracotomy, thoracoscopy)
Exclusion criteria:
Desflurane for pharmacological conditioning
Drug: Desflurane
Drug: Propofol
4-6 Vol %
TIVA to achieve BIS value of 40-60
Major complications as defined as ≥ grade IIIa according to classification of surgical complications from Dindo et al. after lung resection with one-lung ventilation during hospitalization
Time frame: postoperative phase until discharge; 6 month after surgery
Major complications ≥ grade IIIa according to classification of surgical complications from Dindo et al. after dimissio up to 6 months after surgery
Time frame: postoperative phase until discharge, 6 month postoperative
Perioperative inflammatory mediators TNF-α, IL-6, IL-8, sICAM-1, MCP-1, MIP-2 in blood (correlation to complications ≥ grade IIIa according to classification of surgical complications from Dindo et al. during hospitalization)
Time frame: postoperative phase until discharge
This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Desflurane · Propofol