An interventional study of glucose bolus and Glucose sipping in Cardiovascular Disease and Diabetes, sponsored by University of Toronto. Completed. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-03-12.
Sponsored by University of Toronto · Not applicable, Interventional, and Basic science
The objective of this study is to determine the effect of reducing the rate of glucose absorption on oxidative stress after eating and to compare it with the effects of vitamin C. The hypothesis is that reducing the rate of glucose absorption will reduce oxidative stress to a similar extent as 1g vitamin C.
Recently, much attention has been paid to evidence that abnormalities of the postprandial state (hyperglycemia) are important contributing factors to the development of chronic disease. This attention has increased interest in the role low glycemic index (GI) foods could potentially play in preventing postprandial oxidative burst/stress. GI is a means by which to categorize carbohydrate according to their postprandial glycemic response. Low GI foods promote slow intestinal absorption, prolonged and less pronounced postprandial glycemia, may decrease risk of chronic disease, as well as provide metabolic benefit to people living with glucose abnormalities as well as those with normal glucose. Few studies have been conducted looking at the potential relationship between GI and oxidation and are limited by dietary/lifestyle confounders. The proposed study has been developed to eliminate these confounders. Hypotheses (3): 1. Sipping glucose slowly over 3h will result in less oxidative stress than ingesting the same amount of glucose as a bolus over 5min. 2. Sipping glucose will reduce oxidative stress to the same extent as 1g of oral vitamin C. 3. The effect of sipping glucose on oxidative stress will occur sooner than that of vitamin C.
4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.
This study's enrollment of 18 is below the median of 100 across 2,738 interventional studies indexed under Cardiovascular Diseases.
Browse Cardiovascular Diseases studies →University of Toronto is the lead sponsor of 397 studies on the registry; 59 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
50g glucose dissolved in water and consumed within 5 minutes.
Dietary Supplement: glucose bolus
50g glucose dissolved in water and consumed gradually over 3 hours.
Dietary Supplement: Glucose sipping
50g glucose dissolved in water and consumed in 5 minutes with 1g vitamin C
Dietary Supplement: Glucose bolus plus 1g vitamin C
50g glucose dissolved in water and consumed gradually of 3 hours. In addition 1g vitamin C will be taken with the first mouthful of glucose solution.
Dietary Supplement: Glucose sipping plus 1g vitamin C
50g anhydrous glucose dissolved in 300ml water consumed within 10min followed by a lunch (cheese sandwich, fruit and milk) at 4h.
50g anhydrous glucose dissolved in 300ml water consumed at rate of 25ml per 15min followed by a lunch (cheese sandwich, fruit and milk) at 4h.
50g anhydrous glucose dissolved in 300ml water consumed within 10min with 1g vitamin C followed by a lunch (cheese sandwich, fruit and milk) at 4h.
50g anhydrous glucose dissolved in 300ml water consumed at rate of 25ml per 15min. 1g vitamin C taken with first 25ml. Followed by a lunch (cheese sandwich, fruit and milk) at 4h.
Incremental Area Under the Curve over 4 hours in serum TRAP (total peroxyl radical-trapping potential)
Time frame: Four (4) hours after starting to eat the test meal.
Change over 6 hours from baseline in Plasma glucose
Time frame: Baseline and 30, 60, 120, 180, 240, 270, 300 and 360min
Change over 6 hours from baseline in Plasma insulin
Time frame: Baseline and 30, 60, 120, 180, 240, 270, 300 and 360min
Change over 6 hours from baseline in Plasma free-fatty acids
Time frame: Baseline and hourly for 6h
Change over 6 hours from baseline in Serum vitamin C
Time frame: Baseline and 2, 4 and 6h
Change over 6 hours from baseline in C-reactive protein
Time frame: Baseline and 2, 4 and 6h
Change over 6 hours from baseline in Blood pressure
Time frame: Baseline and 1, 2, 4, 5 and 6h
Change over 6 hours from baseline in Pulse
Time frame: Baseline and 1, 2, 4, 5 and 6h
Change over 6 hours from baseline in Pulse pressure
Time frame: Baseline and 1, 2, 4, 5 and 6h
Change over 6 hours from baseline in Augmentation index
Time frame: Baseline and 1, 2, 4, 5 and 6h
Change over 6 hours from baseline in Oxidized LDL
Time frame: Baseline and hourly for 6hr
Change from baseline in serum TRAP over 6 hours
Time frame: Baseline and 30, 60, 120, 180, 240, 270, 300 and 360min
No study locations are listed for this record.
This study is completed, as verified in Mar 2013. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Toronto