An interventional study of Exercise in Overweight, Insulin Resistance and Diabetes Mellitus, Type 2, sponsored by University of Copenhagen. Completed at 1 site in Denmark. Open to male participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-02.
Sponsored by University of Copenhagen · Not applicable, Interventional, and Basic science
The aim of the study is to 1) delineate the molecular mechanisms behind the large variation in insulin sensitivity among apparently healthy subjects and to 2) establish the dose-response relationship between physical training and a) metabolic health, b) appetite and c) cultural health.
3,670 studies on the registry are indexed under Overweight; 849 are open to participants now.
This study's enrollment of 64 is below the median of 73 across 3,175 interventional studies indexed under Overweight.
Browse Overweight studies →University of Copenhagen is the lead sponsor of 450 studies on the registry; 61 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Exercise combusting 600 kcal/day, 7 days/week for 12 weeks.
Behavioral: Exercise
Exercise combusting 300 kcal/day, 7 days/week for 12 weeks.
Behavioral: Exercise
Continued sedentary living.
Daily exercise for 12 weeks.
Change from baseline in insulin sensitivity at 12 weeks
As measured by a hyperinsulinemic, isoglycemic clamp combined with skeletal muscle and adipose tissue biopsies as well as low-dose PET/CT.
Time frame: At baseline and 12 weeks
Change from baseline in body composition af 2, 6 and 12 weeks
As measured by DEXA- and MRI-scanning.
Time frame: At baseline, 2, 6 and 12 weeks
Change from baseline in appetite at 12 weeks
As measured by food records, controlled diets, meal tests and appetite hormones
Time frame: At baseline and 12 weeks
Motivational factors for exercise
Ethnographic field work
Time frame: During and for up to 1½ year after the intervention
Diameter of t-tubuli in skeletal muscle
As measured in skeletal muscle biopsies by electron and confocal microscopy
Time frame: At baseline
This study is completed, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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University of Copenhagen