An observational study in Hemolytic-uremic Syndrome and Escherichia Coli Infections, sponsored by University Hospital, Bordeaux. Completed at 1 site in France. Open to participants aged 2 Years and older. Per ClinicalTrials.gov, last updated 2012-11-20.
Sponsored by University Hospital, Bordeaux · Observational
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The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype. An outbreak of bloody diarrhea followed by HUS begun after a collective meal with 120 persons on June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB).
At least 9 patients, 8 adults and 1 child have been involved in this HUS outbreak, E. coli of the O104:H4 serotype being demonstrated in most patients. This outbreak is remarkable by its preponderance in adults and women, its aggressiveness with multiorgan involvement , i.e. the kidneys, brain, liver, pancreas, and skin.
Pathophysiology, prognosis, and treatment of typical HUS are poorly defined, particularly in adults who are usually not involved in typical E. coli O157H7 HUS.
The aim of the present study is to gain knowledge on these different aspects of the HUS, including response to therapy.
28 studies on the registry are indexed under Hemolytic-Uremic Syndrome; 7 are open to participants now.
This study's enrollment of 9 is below the median of 50 across 13 observational studies indexed under Hemolytic-Uremic Syndrome.
Browse Hemolytic-Uremic Syndrome studies →University Hospital, Bordeaux is the lead sponsor of 807 studies on the registry; 198 are open to participants now.
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dinner guest to a collective meal on June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB).
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: HUS standard coverage care (including in ICU)
HUS standard coverage care : plasmaphereses - eculizumab - Immunoadsorption
Improve scientific knowledge on epidemic HUS in the context of an outbreak of E. coli O104:H4 HUS in the town of Bègles, urban area of Bordeaux, France
This is an observational propspective study in which all data will be collected on all pertinent aspects of disease, including therapeutic regimens.
Time frame: during patient hospitalization
evaluate efficiency of therapeutic and diagnostic strategies
Time frame: during patient hospitalization
The record gives a start of Jul 2011, a primary completion of Mar 2012 and a completion of Mar 2012. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Nov 2012. You cannot join it, but the record below documents what was studied.
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University Hospital, Bordeaux →