CClinicalTrials.gg
CompletedNCT01401270Updated Mar 13, 2019

Prize Contingency Management for Cocaine-Dependent Methadone Patients

An interventional study of prize contingency management in Cocaine Abuse, sponsored by UConn Health. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-03-13.

Sponsored by UConn Health · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
280
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and has 3 prize categories, (c) a contingency management condition that arranges a 31% probability of winning and has 3 prize categories, (d) a contingency management condition that arranges a 100% probability of winning and has 7 prize categories, (e) a contingency management condition that arranges a 31% probability of winning and has 7 prize categories, or (f) usual prize contingency management with a 50% probability of winning from 3 prize categories. Magnitudes of reinforcement will be identical across conditions, but lower overall probability conditions arrange for greater chances of winning larger magnitude prizes. The investigators expect that the new contingency management conditions will reduce cocaine use relative to the control condition, that 31% probability conditions will decrease drug use relative to 100% conditions, and that 7-prize category conditions will reduce drug use compared to 3-prize category conditions. In addition, the 31%/7-category condition is expected to be most efficacious. Results will be instrumental for further developing prize contingency management to improve outcomes of cocaine-dependent methadone patients.

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Conditions studied

  • Cocaine Abuse
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In context

Cocaine-Related Disorders

415 studies on the registry are indexed under Cocaine-Related Disorders; 12 are open to participants now.

This study's enrollment of 280 is above the median of 60 across 312 interventional studies indexed under Cocaine-Related Disorders.

Browse Cocaine-Related Disorders studies →

Lead sponsor

UConn Health is the lead sponsor of 182 studies on the registry; 18 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 6 (67%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • age > 18 years
  • current DSM-IV diagnosis of cocaine dependence
  • enrolled at the clinic for >3 months
  • on a stable dose of methadone (no changes) for >1 month and not requesting a dose alteration
  • submitted >1 clinic cocaine positive sample in the last 6 months
  • English speaking
  • pass a quiz related to understanding the informed consent form

Exclusion criteria

Exclusion Criteria:

  • serious, uncontrolled psychiatric illness
  • significant cognitive impairment
  • in recovery from pathological gambling
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
280 participants (actual)

Study arms

  • No intervention
    Treatment Group A

    Standard Care

  • Experimental
    Treatment Group B

    100% probability of winning a prize with each draw and has 3 prize categories

    Behavioral: prize contingency management

  • Experimental
    Treatment Group C

    31% probability of winning and has 3 prize categories

    Behavioral: prize contingency management

  • Experimental
    Treatment Group D

    100% probability of winning and has 7 prize categories

    Behavioral: prize contingency management

  • Experimental
    Treatment Group E

    31% probability of winning and has 7 prize categories

    Behavioral: prize contingency management

  • Experimental
    Treatment Group F

    usual prize contingency management with a 50% probability of winning from 3 prize categories

    Behavioral: prize contingency management

Interventions

  • Behavioralprize contingency management

    Participants earn the chance to win prizes for the targeted behavior, cocaine abstinence.

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What researchers measure

Primary outcomes

  1. longest continuous period of cocaine abstinence

    Time frame: three months

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Study locations

1 site
  • University of Connecticut Health Center
    Farmington, Connecticut 06030, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 13, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01401270
Lead sponsor
UConn Health
Collaborators
National Institute on Drug Abuse (NIDA)
Responsible party
Sheila Alessi (Associate Professor, UConn Health) — Principal investigator
First posted
Jul 25, 2011
Start date
Nov 2011
Primary completion
May 2018
Completion
May 2018
Last update
Mar 13, 2019

Study contacts

Sheila M Alessi, Ph.D.
principal investigator · UConn Health

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2019. You cannot join it, but the record below documents what was studied.

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