CClinicalTrials.gg
CompletedNCT01398306BANNUpdated May 6, 2024

Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.

An observational study in Carcinoma, Carcinoma, Renal Cell and Neuroendocrine Tumors, sponsored by University Medical Center Groningen. Completed at 1 site in Netherlands. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-05-06.

Sponsored by University Medical Center Groningen · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
40
Ages
18 Years and older
Sex
All
01

Study summary

The primary objective of this study is to analyse the concentration dopamine and serotonin in thrombocytes of patients with renal cell carcinoma and neuro-endocrine tumours compared to the concentrations of these catecholamines in healthy volunteers. The concentration dopamine and serotonin in thrombocytes with and without medication will also be evaluated.

Read the detailed description
  • To analyse the concentration catecholamines in thrombocytes of patients with clear cell renal cell carcinoma and low grade neuroendocrine tumours.
  • To compare these concentrations with the concentrations catecholamines in thrombocytes of healthy controls.
  • To analyse the concentration catecholamines in thrombocytes of patients with clear cell renal cell carcinoma and patients with low grade neuroendocrine tumours with and without medication.
02

Conditions studied

  • Carcinoma
  • Carcinoma, Renal Cell
  • Neuroendocrine Tumors
  • Carcinoid Tumor
  • Pancreatic Islet Cell Tumors

Keywords

  • Angiogenesis Inhibitors
  • Neoplasms, Glandular and Epithelial
  • Neoplasms by Histologic Type
  • Neoplasms
  • Adenocarcinoma
  • Kidney Neoplasms
  • Urologic Neoplasms
  • Urogenital Neoplasms
  • Neoplasms by Site
  • Kidney Diseases
  • Angiogenesis Inducing Agents
  • Biological Markers
03

In context

Carcinoma

6,741 studies on the registry are indexed under Carcinoma; 1,161 are open to participants now.

This study's enrollment of 40 is below the median of 149 across 1,175 observational studies indexed under Carcinoma.

Browse Carcinoma studies →

Lead sponsor

University Medical Center Groningen is the lead sponsor of 609 studies on the registry; 174 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients with clear cell renal cell carcinoma with metastases and patients with low grade neuroendocrine tumours with metastases.

Inclusion criteria

  • Age 18 years old or older.
  • Patients with clear cell renal cell carcinoma with metastases or patients with a low-grade neuro-endocrine tumor with metastases.
  • Written informed consent

Exclusion criteria

Exclusion Criteria:

  • Use of L-dopa or SSRI.
  • Patients with a second primary malignancy.
05

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
40 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Group A

    Patients with clear cell renal cell carcinoma with metastases.

    Other: Blood sampling by vena punction.

  • Group B

    Patients with low grade neuro-endocrine tumours with metastases.

    Other: Blood sampling by vena punction.

Interventions

  • OtherBlood sampling by vena punction.

    We obtain 10mL blood of the patients. The blood is obtained twice: once with angiogenesis inhibitors or mTOR inhibitors, and once without.

06

What researchers measure

Primary outcomes

  1. Difference in concentrations DA and 5-HT in thrombocytes of patients with clear cell renal cell carcinoma and healthy controls, and patients with low grade neuroendocrine tumours and healthy controls.

    Time frame: one year

Secondary outcomes

  1. Difference in concentrations DA and 5-HT in thrombocytes of patients with clear cell renal cell carcinoma and low grade neuroendocrine tumours with and without medication.

    Time frame: one year

07

Study locations

1 site
  • University Medical Center Groningen
    Groningen, 9700RB, Netherlands
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 6, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01398306
Lead sponsor
University Medical Center Groningen
Responsible party
Sponsor
First posted
Jul 20, 2011
Start date
Jul 2011
Primary completion
Apr 2012
Completion
Apr 2012
Last update
May 6, 2024

Study contacts

Sjoukje F. Oosting, MD
study chair · University Medical Center Groningen
Marloes A.M. Peters
principal investigator · University Medical Center Groningen

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.

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