An interventional study of exercise training in Chronic Obstructive Pulmonary Disease and Alpha-1-antitrypsin-deficiency, sponsored by Schön Klinik Berchtesgadener Land. Completed at 1 site in Germany. Open to participants aged 40 Years to 75 Years. Per ClinicalTrials.gov, last updated 2013-12-17.
Sponsored by Schön Klinik Berchtesgadener Land · Not applicable, Interventional, and Basic science
Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.
94 studies on the registry are indexed under Alpha 1-Antitrypsin Deficiency; 5 are open to participants now.
This study's enrollment of 20 is below the median of 27 across 58 interventional studies indexed under Alpha 1-Antitrypsin Deficiency.
Browse Alpha 1-Antitrypsin Deficiency studies →Schön Klinik Berchtesgadener Land is the lead sponsor of 51 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
Procedure: exercise training
strength and endurance training, 5 time per week.
Also known as: endurance training, strength training
aerobic and anaerobic enzymes
changes in quantity of enzymes from baseline to day 23
Time frame: day 2 and 23
maximal exercise capacity in incremental cycling test
Change in max. exercise capacity from baseline to day 23
Time frame: day 2 and 23
6-minute-walking distance
change in 6-minute-walking distance from baseline to day 24
Time frame: day 3 and 24
This study is completed, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.
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Alpha 1-Antitrypsin Deficiency→
Schön Klinik Berchtesgadener Land