An interventional study of Rehabilitation combined to a digital maintenance program and Rehabilitation without maintenance program in Post-COVID-19 Syndrome, sponsored by Schön Klinik Berchtesgadener Land. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by Schön Klinik Berchtesgadener Land · Not applicable, Interventional, and Treatment
Infection with SARS-CoV-2 virus leads to persistent symptoms for more than 12 weeks in 15% of cases ("post-COVID syndrome"). Symptoms like fatigue, dyspnoea, limitations in physical performance and activities, head ache, anxiety symptoms, and depression are heterogenous which limit physical health and participation in daily life activities.
In the last years, multidisciplinary rehabilitation programs showed benefits in quality of life and symptom intensity in patients with post-COVID. Therefore, rehabilitation programs are recommended for individuals with Post-COVID by official sites like the German Society of Pulmonology and the European Respiratory Society.
Own first data (published at the ERS conference 2023) revealed that one the one hand, inpatient rehabilitation is effective, however, on the other hand, it is challenging to maintain these effects after completing the program. Therefore, the aim of this study is to sustain these benefits by using a digital maintenance program following the rehabilitation program compared to usual care.
520 studies on the registry are indexed under Post-Acute COVID-19 Syndrome; 186 are open to participants now.
This study's enrollment of 90 is above the median of 60 across 361 interventional studies indexed under Post-Acute COVID-19 Syndrome.
Browse Post-Acute COVID-19 Syndrome studies →Schön Klinik Berchtesgadener Land is the lead sponsor of 51 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Procedure: Rehabilitation combined to a digital maintenance program
Procedure: Rehabilitation without maintenance program
Individuals in this group undergo a 3-week inpatient rehabilitation program followed by a 12-week maintenance program (2 sessions per week à 90 minutes, digital and live). The multimodal programs consist of physiotherapy, training therapy, medical support, cognitive training, education and psychological support.
Individuals in this group undergo a 3-week inpatient rehabilitation program followed by a 12-week usual care period.
Change from baseline quality of life assessed by Short-Form 12 questionnaire at week 4 and week 19
The scale of the physical and mental Health component summary score ranges from minimum 0 to maximum 100 points with higher scores indicating better quality of life
Time frame: Baseline, week 4, week 19
Change from baseline post-COVID-related symptoms at week 4 and week 19
The number of COVID-symptoms will recorded as well as their intensity will be rated on a scale from 0 \[not relevant\] until 10 \[very severe symptom\].
Time frame: Baseline, week 4, week 19
Change from baseline lung function at week 4 and week 19
following Parameters will be collected:Pimax
Time frame: Baseline, week 4, week 19
Change from baseline fatigue symptoms at week 4 and week 19
Fatigue Assessment Scale will be used
Time frame: Baseline, week 4, week 19
Change from baseline exercise capacity at week 4 and week 19
1-minute sit to stand test will be performed (maximum repetitions of squats in one minute)
Time frame: Baseline, week 4, week 19
Change from baseline physical activity at week 4 and week 19
Activity will be measure in steps per day using a wearable from Polar
Time frame: Baseline, week 4, week 19
Change from baseline quality of life at week 4 and week 19
EQ-5D-5L questionnaire will be used.
Time frame: Baseline, week 4, week 19
Change from the use of health care service at week 4 and week 19
Frequency of therapeutical, medical and psychological sessions will be documented.
Time frame: Baseline, week 4, week 19
Change from the use of medications at week 4 and week 19
Amount and kind of medication will be documented.
Time frame: Baseline, week 4, week 19
Change from rate of sickness at week 4 and week 19
Days of sickness will be documented.
Time frame: Baseline, week 4, week 19
Change from workability at week 4 and week 19
Work ability index will be used
Time frame: Baseline, week 4, week 19
Change from ICF functionality at week 4 and week 19
Indicators of rehabilitation status questionnaire (IRES-3) will be used.
Time frame: Baseline, week 4, week 19
Change from sleep quality at week 4 and week 19
Sleep quality will be assessed by using the Pittsburgh Sleep Quality Index (total score ranges from 0 to 21 with higher scores indicating higher impairment)
Time frame: Baseline, week 4, week 19
Change from depression symptoms at week 4 and week 19
Patient Health Questionnaire 9 will be used. The total score ranges from 0 to 27 points with higher scores indicating worse Depression symptoms
Time frame: Baseline, week 4, week 19
Change from anxiety symptoms at week 4 and week 19
Generalized Anxiety Disorder Scale 7 will be used. The total score ranges from 0 to 21 points with higher scores indicating more anxiety symptoms
Time frame: Baseline, week 4, week 19
Change from resilience at week 4 and week 19
Resilience scale RS-13 will be used.
Time frame: Baseline, week 4, week 19
Change from cognition at week 4 and week 19
Cognition will be measured via the software RehaCom (by Hasomed GmbH).
Time frame: Baseline, week 4, week 19
Change from cognitive impairment at week 4 and week 19
Cognitive impairment will be measured by Montreal Cognitive Assessment (MoCA)
Time frame: Baseline, week 4, week 19
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Schön Klinik Berchtesgadener Land