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Status unknownNCT01344928HITPETUpdated Apr 29, 2011

The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes

An interventional study of HIT exercise intervention and Aerobic exercise intervention in Type 2 Diabetes Mellitus and Healthy Volunteers, sponsored by Turku University Hospital. Status unknown at 1 site in Finland. Open to male participants aged 40 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-04-29.

Sponsored by Turku University Hospital · Not applicable and Interventional

The sponsor has not verified this record recently (last verified Apr 2011), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Ages
40 Years to 55 Years
Sex
Male
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Study summary

The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).

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Conditions studied

  • Type 2 Diabetes Mellitus
  • Healthy Volunteers
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In context

Diabetes Mellitus, Type 2

9,359 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,318 are open to participants now.

Browse Diabetes Mellitus, Type 2 studies →

Lead sponsor

Turku University Hospital is the lead sponsor of 280 studies on the registry; 65 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years to 55 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

The healthy patients

  1. Age 40-55
  2. BMI 18.5-30
  3. Fasting plasma glucose less than 6.1 mmol/l
  4. Normal glucose tolerance test (OGTT)

The type 2 diabetic patients:

  1. Age-, sex-, and BMI-matched with the study subjects in the phase 1
  2. In a good treatment balance
  3. Glycated haemoglobin (HbA1c) less than 7.5 mmol/l
  4. Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l

Exclusion criteria

Exclusion Criteria:

The healthy patients

  1. Blood pressure > 140/90 mmHg
  2. Any chronic disease
  3. Any chronic medical defect or injury which hinder/interfere everyday life
  4. History of anorexia nervosa or bulimia
  5. History of rest or exercise-induced asthma
  6. Previous use of anabolic steroids, additives or any other substrates
  7. Smoking of tobacco, taking of snuffs, or use of narcotics.
  8. Significant use of alcohol
  9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  10. Presence of any ferromagnetic objects that would make MR imaging contraindicated
  11. Current or history of regular and systematic exercise training
  12. VO2max >40 ml/min/kg

The type 2 diabetic patients:

  1. Any other chronic disease than diabetes
  2. Blood pressure > 140/90 mmHg
  3. Any chronic medical defect or injury which hinder/interfere everyday life
  4. History of anorexia nervosa or bulimia
  5. History of rest or exercise-induced asthma
  6. Smoking of tobacco, taking of snuffs, or use of narcotics.
  7. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  8. Presence of any ferromagnetic objects that would make MRI imaging contraindicated
  9. Current or history of regular and systematic exercise training
  10. VO2max >40 ml/ min/kg
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Study design

Phase
Not applicable

Study arms

  • Experimental
    HIT training

    Behavioral: HIT exercise intervention

  • Active comparator
    Aerobic exercise training

    Behavioral: Aerobic exercise intervention

Interventions

  • BehavioralHIT exercise intervention
  • BehavioralAerobic exercise intervention
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Study locations

1 of 1 sites recruiting
  • Turku PET Centre
    Turku, 20521, Finland
    • Jarna C Hannukainen, PhD · Contact · jarna.hannukainen@tyks.fi · +358-2-3131878
    • Jarna C Hannukainen, PhD · Principal investigator
    • Kari K Kalliokoski, PhD · Sub investigator
    • Joonas J Eskelinen, BM · Sub investigator
    • Anna Savolainen, BM · Sub investigator
    • Ilkka Heinonen, PhD · Sub investigator
    • Kirsi A Virtanen, PhD · Sub investigator
    • Jukka Kemppainen, PhD · Sub investigator
    • Juhani Knuuti, Professor · Sub investigator
    • Pirjo Nuutila, Professor · Sub investigator
    • Jussi Pärkkä, MD · Sub investigator
    • Virva Lepomäki, MSc · Sub investigator
    • Riitta Parkkola, MD, PhD · Sub investigator
    Recruiting
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References and documents

Publications

  • Ojala R, Motiani KK, Ivaska KK, Arponen M, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Heiskanen MA, U-Din M, Nuutila P, Kalliokoski KK, Hannukainen JC. Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training. J Clin Endocrinol Metab. 2020 Dec 1;105(12):e4290-303. doi: 10.1210/clinem/dgaa516. PubMed 32785654 ↗
  • Motiani KK, Collado MC, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Salminen S, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia. Med Sci Sports Exerc. 2020 Jan;52(1):94-104. doi: 10.1249/MSS.0000000000002112. PubMed 31425383 ↗
  • Heiskanen MA, Motiani KK, Mari A, Saunavaara V, Eskelinen JJ, Virtanen KA, Koivumaki M, Loyttyniemi E, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial. Diabetologia. 2018 Aug;61(8):1817-1828. doi: 10.1007/s00125-018-4627-x. Epub 2018 May 2. PubMed 29717337 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 29, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01344928
Lead sponsor
Turku University Hospital
Collaborators
European Foundation for the Study of Diabetes, Ministry of Education and Culture, Finland, Orion Farmos Research Foundation, Academy of Finland, Turku PET Centre, University of Turku, Verve Research, Oulu, Finland, University of Helsinki
First posted
Apr 29, 2011
Last update
Apr 29, 2011

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2011. You cannot join it, but the record below documents what was studied.

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