An interventional study of Percutaneous coronary intervention in Coronary Artery Stenosis, sponsored by St. Anne's University Hospital Brno, Czech Republic. Completed at 1 site in Czech Republic. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-01-01.
Sponsored by St. Anne's University Hospital Brno, Czech Republic · Not applicable, Interventional, and Treatment
The aim of the study is to find the optimal management of patients with acute myocardial infarction with ST elevations treated by primary PCI who have at least one significant stenosis of non-culprit coronary artery. The primary endpoint of the study will be incidence of combined endpoint of all cause mortality, nonfatal myocardial infarction and stroke during the follow up of 24 months in group of patients treated with staged revascularization (PCI or CABG) in comparison with patients treated conservatively.
Introduction:
Primary percutaneous coronary intervention (PPCI) of the occlussion or significant stenosis of infarct artery is a method of choice in treatment of acute myocardial infarction with ST segment elevation (STEMI). It is not clear, what is the optimal management of patients with acute myocardial infarction with ST elevations (STEMI) treated by primary percutaneous coronary intervention (PPCI) who have at least one significant stenosis of non-culprit coronary artery. Numerous cardiology centers perform staged PCI on significant stenoses involving the "non-infarct" coronary artery (arteries) 3-40 days after PPCI, but the benefit of this staged PCI for such patients has not yet been clearly demonstrated.
Aim of study:
The aim is to find the optimal management of patients with acute myocardial infarction with ST elevations (STEMI) treated by PPCI who have at least one significant stenosis of non-culprit coronary artery. The primary endpoint of the study will be incidence of combined endpoint of all cause mortality, nonfatal myocardial infarction and stroke during the follow up of 24 months in group of patients treated with staged revascularization (PCI or CABG) in comparison with patients treated conservatively.
Hypothesis:
Our hypothesis is that complete staged revascularization of significant stenoses of the coronary arteries will improve the long-term prognosis in patients after PPCI as compared to conservative management.
302 studies on the registry are indexed under Coronary Stenosis; 63 are open to participants now.
This study's enrollment of 213 is close to the median of 200 across 160 interventional studies indexed under Coronary Stenosis.
Browse Coronary Stenosis studies →St. Anne's University Hospital Brno, Czech Republic is the lead sponsor of 24 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Percutaneous coronary intervention of "non-infarct" coronary arteries
Procedure: Percutaneous coronary intervention
standard guideline-based medical therapy
PCI of significant stenoses of "non-infarct" coronary arteries
composite endpoint of death, nonfatal acute myocardial infarction and stroke
Time frame: 2 years
cardiovascular death
Time frame: 2 years
recurrent myocardial infarction
Time frame: 2 years
target vessel failure
progression of studied stenosis of non-culprit artery
Time frame: 2 years
stroke
Time frame: 2 years
hospitalization for heart failure
Time frame: 2 years
changes of left ventricular ejection fraction
Time frame: 2 years
hospitalization for unstable angina pectoris
Time frame: 2 years
outcomes of questionnaire regarding angina pectoris
Time frame: 2 years
target vessel revascularization
non infarct artery
Time frame: 2 years
target lesion revascularization
non infarct artery
Time frame: 2 years
This study is completed, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
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St. Anne's University Hospital Brno, Czech Republic