An interventional study of cetirizine 10 mg and fluticasone furoate in Seasonal Allergic Rhinitis, Driving Ability and Cognition, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to participants aged 21 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-11-08.
Sponsored by Maastricht University Medical Center · Not applicable and Interventional
This study investigates the effects of Allergic Rhinitis (AR) on driving ability and memory functions. Our group has previously shown that patients suffering from AR symptoms perform less well on tasks requiring sustained attention compared to non symptomatic controls. Car driving is a typical behavior that is susceptible for changes in sustained attention and might therefore become worse under conditions when patients suffer from AR symptoms. We will compare the driving performance of untreated, symptomatic AR patients with the performance of symptomatic patients that have been treated with either a systemic AR medication (a pill) or a topical medication (nasal spray)
1,105 studies on the registry are indexed under Rhinitis; 65 are open to participants now.
This study's enrollment of 22 is below the median of 89 across 906 interventional studies indexed under Rhinitis.
Browse Rhinitis studies →Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Subjects are treated with Cetirizine 10 mg after a nasal challenge with a pollen solution
Drug: cetirizine 10 mg
treatment with 25ug fluticasone furoate after a nasal pollen challenge
Drug: fluticasone furoate
Placebo treatment after a nasal challenge with pollen solution
Drug: placebo
A placebo drug is administered after a sham nasal challenge with a pollen solution
cetirizine 10 mg over encapsulated
nasal spray 25ug per dose
a placebo nasal spray and placebo capsule are available for double dummy treatment
Standard Deviation of Lateral Position (SDLP) in highway driving
Standard Deviation of Lateral Position (SDLP) is the amount of "weaving" that occurs when a person is driving in a straight line on the highway and instructed to maintain a steady speed and position within the lane he/she is driving
Time frame: 2:00 - 3:00 hrs post dosing
Word Learning Test (WLT-15) verbal memory score
Subjects are presented with a list of 15 words at a rate of one word/second with a pause between words of one second. Immediately following the presentation subjects are asked to recall and name as many words as possible. The total number of words recalled after three repeated presentations of the same list of words is the outcome variable
Time frame: 2:30 hrs post dosing
This study is completed, as verified in Mar 2011. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Maastricht University Medical Center