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CompletedNCT01309334IMAJEMUpdated Sep 14, 2026

Imaging Young Myeloma (IMAgerie JEune Myélome)

A Phase 3 interventional study of PET scan and MRI in Multiple Myeloma, sponsored by Nantes University Hospital. Completed at 17 sites in France. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-14.

Sponsored by Nantes University Hospital · Phase 3, Interventional, and Diagnostic

Phase
Phase 3
Study type
Interventional
Enrollment
152
Allocation
Not applicable
Ages
18 Years to 65 Years
Sex
All
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Study summary

Multicenter open-label prospective comparative study of PET-scan and MRI at the time of diagnosis, after 3 cycles of induction therapy (RVD) and at the completion of therapy.

02

Conditions studied

  • Multiple Myeloma

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Keywords

  • MRI
  • PET-scan
  • multiple myeloma
  • prognosis
  • pharmacoeconomic analysis
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In context

Multiple Myeloma

3,632 studies on the registry are indexed under Multiple Myeloma; 745 are open to participants now.

This study's enrollment of 152 is above the median of 41 across 2,907 interventional studies indexed under Multiple Myeloma.

Browse Multiple Myeloma studies →

Lead sponsor

Nantes University Hospital is the lead sponsor of 825 studies on the registry; 195 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • symptomatic de novo multiple myeloma
  • less than 65 years of age
  • enrolled in the IFM/DFCI clinical trial

Exclusion criteria

Exclusion Criteria:

  • 66 years of age or more
  • not eligible for high-dose therapy
  • Cons-indications to MRI or PET-Scan
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Study design

Phase
Phase 3
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
152 participants (actual)

Interventions

  • ProcedurePET scan

    Performed at diagnosis, after 3 cycles of induction therapy, and at completion of therapy

  • ProcedureMRI

    Performed at diagnosis, after 3 cycles of induction therapy, and at completion of therapy

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What researchers measure

Primary outcomes

  1. Number of patients with at least one lesion not detected on the MRI lesions

    Time frame: At diagnosis

Secondary outcomes

  1. Negativity of the exam after 3 cycles of chemotherapy and just before the maintenance treatment

    Time frame: 3 months and 7 months

  2. Number of lesions at diagnosis

    Time frame: Inclusion (diagnosis)

  3. diffuse disease at diagnosis

    Time frame: Diagnosis time (inclusion)

  4. Direct costs of PET and MRI at diagnosis, after the first cycles of chemotherapy and before the maintenance treatment

    Time frame: Inclusion, 3 months and 7 months

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Study locations

17 sites
  • Bordeaux University Hospital
    Bordeaux, France
  • Brest University Hospital "CHU du Morvan"
    Brest, France
  • Hospital "Côte de Nacre"
    Caen, France
  • Clermont-Ferrand University Hospital
    Clermont-Ferrand, France
  • Dijon University Hospital
    Dijon, France
  • Grenoble University Hospital "Hôpital Michallon"
    Grenoble, France
  • Le Mans Hospital
    Le Mans, France
  • Lille University Hospital "Claude Huriez"
    Lille, France
  • Lyon University Hospital
    Lyon, France
  • "Institut Paoli Calmettes"
    Marseille, France
  • Metz University Hospital "Hôpital de Mercy"
    Metz, France
  • Nancy University Hospita "Hôpitaux de Brabois"
    Nancy, France
  • Nantes University Hospital
    Nantes, 44000, France
  • APHP "Hôpital Saint-Antoine"
    Paris, France
  • Rennes University Hospital
    Rennes, France
  • Toulouse University Hospital
    Toulouse, France
  • Tours University Hospital "Hôpital Bretonneau"
    Tours, France
08

References and documents

Publications

  • Moreau P, Attal M, Caillot D, Macro M, Karlin L, Garderet L, Facon T, Benboubker L, Escoffre-Barbe M, Stoppa AM, Laribi K, Hulin C, Perrot A, Marit G, Eveillard JR, Caillon F, Bodet-Milin C, Pegourie B, Dorvaux V, Chaleteix C, Anderson K, Richardson P, Munshi NC, Avet-Loiseau H, Gaultier A, Nguyen JM, Dupas B, Frampas E, Kraeber-Bodere F. Prospective Evaluation of Magnetic Resonance Imaging and [18F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study. J Clin Oncol. 2017 Sep 1;35(25):2911-2918. doi: 10.1200/JCO.2017.72.2975. Epub 2017 Jul 7. PubMed 28686535 ↗
  • Zamagni E, Nanni C, Dozza L, Carlier T, Bailly C, Tacchetti P, Versari A, Chauvie S, Gallamini A, Gamberi B, Caillot D, Patriarca F, Macro M, Boccadoro M, Garderet L, Barbato S, Fanti S, Perrot A, Gay F, Sonneveld P, Karlin L, Cavo M, Bodet-Milin C, Moreau P, Kraeber-Bodere F. Standardization of 18F-FDG-PET/CT According to Deauville Criteria for Metabolic Complete Response Definition in Newly Diagnosed Multiple Myeloma. J Clin Oncol. 2021 Jan 10;39(2):116-125. doi: 10.1200/JCO.20.00386. Epub 2020 Nov 5. PubMed 33151787 ↗
  • Jamet B, Morvan L, Nanni C, Michaud AV, Bailly C, Chauvie S, Moreau P, Touzeau C, Zamagni E, Bodet-Milin C, Kraeber-Bodere F, Mateus D, Carlier T. Random survival forest to predict transplant-eligible newly diagnosed multiple myeloma outcome including FDG-PET radiomics: a combined analysis of two independent prospective European trials. Eur J Nucl Med Mol Imaging. 2021 Apr;48(4):1005-1015. doi: 10.1007/s00259-020-05049-6. Epub 2020 Oct 2. PubMed 33006656 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01309334
Lead sponsor
Nantes University Hospital
Collaborators
Ministry of Health, France
Responsible party
Sponsor
First posted
Mar 7, 2011
Start date
Feb 2011
Primary completion
Sep 2013
Completion
Sep 2013
Last update
Sep 14, 2026

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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