Status unknownNCT01297816minocyclin &RDUpdated Feb 17, 2011

Evaluation of Neuroprotective Effect of Minocycline

A Phase 2 interventional study of placebo and Minocycline in Retinal Detachment, sponsored by Shahid Beheshti University of Medical Sciences. Status unknown at 1 site in Iran, Islamic Republic of. Open to participants aged 8 Years and older. Per ClinicalTrials.gov, last updated 2011-02-17.

Sponsored by Shahid Beheshti University of Medical Sciences · Phase 2, Interventional, and Prevention

The sponsor has not verified this record recently (last verified Dec 2010), so the status shown — last known as Recruiting — may be out of date.

Phase: Phase 2
Study type: Interventional
Allocation: Randomized
Ages: 8 Years and older
Sex: All

Study summary

This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .

Process of degeneration begins from first hours of RD (Retinal Detachment) establishment Neuroprotection of photoreceptor following RD is a novel and debatable discussion encountered in recent years .

How to stop this phenomena and neuroprotective agent role in this issue are a new interest of researcher.

In the study the investigators are planning to perform a clinical trial to demonstrate the minocycline neuroprotective effect in a double blind design as this impact has been implicated previously in a animal study

Conditions studied

Retinal Detachment

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Retinal Detachment 207

In context

Retinal Detachment

207 studies on the registry are indexed under Retinal Detachment; 27 are open to participants now.

Browse Retinal Detachment studies →

Lead sponsor

Shahid Beheshti University of Medical Sciences is the lead sponsor of 221 studies on the registry; 19 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 8 Years and older
Sexes eligible: All
Accepts healthy volunteers: No

Inclusion criteria

age over 8 years old
gender of both sex
normal liver and renal function
informed consent received from all patients
no pregnancy and no lactation
minimal sun exposure

Exclusion criteria

Exclusion Criteria:

old RD
diabetic retina
previous retinal surgery CRF\& liver disfunction RD + PVR > B Hyper sensitivity to tetracycline History previous MPC or PRP Patients unsuccessful SB (retina is off )

Study design

Phase: Phase 2
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Single group
Masking: Double (Participant, Investigator)

Study arms

Placebo comparator
placebo
100mg-
Drug: placebo
Placebo comparator
minocyclin
Drug: Minocycline

Interventions

Drugplacebo
100mg,BD, fo three month
DrugMinocycline
100mg

What researchers measure

Primary outcomes

BCVA
outcome method of measurement: Snellen chart
Time frame: changes of BCVA in 3 month

Secondary outcomes

finding of ERG changes
outcome method of measurement: ERG( testes)
Time frame: 3 months
finding of OCT changes
outcome method of measurement: OCT
Time frame: 3 months
finding of FAF changes
outcome method of measurement: FAF( testes)
Time frame: 3 months

Study locations

1 of 1 sites recruiting

Labbafinejad medical center
Tehran, Iran, Islamic Republic of
- Mohsen Azarmina, Associate Professor · Contact · labbafi@hotmail.com · 00982122585952
- Mohsen Azarmina, Associate Professor · Principal investigator
Recruiting

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Feb 17, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01297816
Lead sponsor: Shahid Beheshti University of Medical Sciences
First posted: Feb 17, 2011
Start date: Dec 2010
Primary completion: Dec 2010 (estimated)
Completion: Apr 2011 (estimated)
Last update: Feb 17, 2011

Oversight

Data monitoring committee: Yes

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Dec 2010. You cannot join it, but the record below documents what was studied.

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Discussion

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