An observational study in Suspected Arterial Hypertension, sponsored by Klinikum Wels-Grieskirchen. Completed at 10 sites in 7 countries. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-04-03.
Sponsored by Klinikum Wels-Grieskirchen · Observational
The investigators aim to investigate whether central systolic blood pressure, as measured during regular 24 hour ambulatory blood pressure monitoring (ABPM), is a better predictor of left ventricular mass than peripheral systolic blood pressure during ABPM.
It seems obvious that central blood pressures are pathophysiologically more relevant than peripheral blood pressures for the pathogenesis of cardiovascular disease: it is central systolic pressure (cSBP) against the heart ejects (afterload), and it is central pulse pressure (cPP) that distends the large elastic arteries. Indeed, cSBP and cPP have been associated more closely with left ventricular hypertrophy and carotid atherosclerosis as markers of hypertensive end-organ damage than brachial pressures in various populations. However, in these studies office blood pressure measurements have been used. As ABPM measurements per se show a closer association with hypertensive end-organ damage than office measurements, and as the investigators have recently developed and validated a novel algorithm (ARCSolver) to calculate central blood pressures from peripheral waveforms, the investigators speculate that cSBP measured during ABPM may be the best predictor of left ventricular mass.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's enrollment of 350 is above the median of 210 across 1,359 observational studies indexed under Hypertension.
Browse Hypertension studies →Klinikum Wels-Grieskirchen is the lead sponsor of 4 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
community sample
> 18 years of age,
Exclusion Criteria:
Other: no intervention performed
no intervention is performed
Left ventricular mass (m-mode echocardiography)
Time frame: measured within 4 weeks from ABPM
urine albumine / creatinine ratio
Time frame: measured within 2 weeks from ABPM but before antihypertensive treatment is started
This study is completed, as verified in Mar 2015. You cannot join it, but the record below documents what was studied.
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Klinikum Wels-Grieskirchen