An interventional study of Scaling and root planing plus placebo and Scaling and root planing plus azythromycin in Diabetes, Gingivitis and Periodontitis, sponsored by Universidad de Antioquia. Completed at 1 site in Colombia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-05-29.
Sponsored by Universidad de Antioquia · Not applicable, Interventional, and Treatment
Diabetes is a metabolic disorder that affects the uptake of glucose into cells. This causes a cascade of systemic alterations that may lead to kidney failure, cardiovascular complications, altered tissue healing, retinopathies and gangrene. Diabetes is also associated to increased susceptibility to infections and inflammation.
It has been observed that diabetic patients suffer more often from oral infections such as periodontal disease. Periodontal disease is an infectious-inflammatory disease that leads to destruction of the surrounding tissues of the tooth. It is proposed that the mechanisms responsible for systemic complication are implicated in the development of periodontal disease. This has been evaluated in studies where diabetic patients showed increased levels of inflammatory cytokines, subgingival bacteria and limited response to treatment. Its has also been suggested that established periodontitis in the diabetic patient leads to insulin resistance due to infection and liberation of cytokines from periodontal tissues and thus worsening the diabetic condition.
This study is aimed to establish the response to periodontal treatment with antibiotics and the kinetics of glucose levels in diabetic patients.
591 studies on the registry are indexed under Gingivitis; 104 are open to participants now.
This study's enrollment of 90 is above the median of 63 across 479 interventional studies indexed under Gingivitis.
Browse Gingivitis studies →Universidad de Antioquia is the lead sponsor of 79 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Drug: Scaling and root planing plus placebo
Drug: Scaling and root planing plus azythromycin
Drug: Prophylaxis plus azythromycin
Single session of scaling and root planing using ultrasonic device. placebo tablets 500 mg, 1 tablet every 24 hours for 3 days
Single session of scaling and root planing using ultrasonic device. Azythromycin tablets 500mg. 1 tablet every 24 hours for 3 days.
Dental polishing using prophylaxis paste and rubber cups. Azythromycin tablets 500mg. 1 tablet every 24 hours for 3 days.
Glycated hemoglobin
Time frame: 1 year
Bleeding on probing
A sign of gingival inflammation
Time frame: 1 year
Clinical attachment level
Time frame: 1 year
Plaque index
Time frame: 1 year
Glycemia
Time frame: 1 year
Probing depth
Time frame: 1 year
This study is completed, as verified in May 2013. You cannot join it, but the record below documents what was studied.
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Universidad de Antioquia