ClinicalTrials.gg
CompletedNCT01264653Updated Jul 6, 2012

Study of Intracameral Adrenaline for Pupil Dilation Without Topical Mydriatics in Refractive Cataract Surgery

An interventional study of adrenalin in Cataract, sponsored by Wenzhou Medical University. Completed at 1 site in China. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2012-07-06.

Sponsored by Wenzhou Medical University · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
40 Years to 80 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 32 studies in Cataract by Wenzhou Medical University — 3 open to participants now, 6 under way, none of them phase 3. Cataract · Wenzhou Medical University.

Enrollment
6th of 14
60 · median 60
Started
2010
with 1 other
No phase
14 of 32
1 open now
Registered
3rd of 32
by date

Among the 32 studies in Cataract by Wenzhou Medical University, this one is the 6th largest by enrollment of the 14 interventional ones that give a count, is one of 2 that started in 2010, is one of 14 with no phase, and was the 3rd registered.

Cataract

1,630 studies on the registry are indexed under Cataract; 235 are open to participants now.

Browse Cataract studies →

Open to participants now

3 of the 32 studies in Cataract by Wenzhou Medical University are open now, in 1 country. Recruiting first, the newest first:

By country, each count listing its studies:

All 3 open studies →

Where they have run

Who these studies take

Of the 142 Cataract studies recruiting now, 88 (62%) set no upper age limit and 8 (6%) stop at 75 or younger; 10 take children under 18; 16 take healthy volunteers.

This study: 40 Years to 80 Years · all sexes · no healthy volunteers.

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02

Study summary

The purpose of this study is to study the safety and efficacy of intracameral adrenaline for pupil dilation without topical mydriatics in refractive cataract surgery.

03

Conditions studied

  • Cataract

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Keywords

  • cataract
04

Who can participate

Ages eligible
40 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • male and female
  • can read and sign form;
  • Clinical diagnosis of cataract
  • Cataract density grade II-III according to the Emery-Little system classification system

Exclusion criteria

Exclusion Criteria:

  • sensitivity to adrenalin;
  • sensitivity to topical mydriatics;
  • any other ocular surgeries;
  • iris abnormalities
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    experimental group,control group

    Intraocular adrenalin,topical mydriatics, experimental group: Intervention: Procedure:refractive cataract surgery with Intraocular adrenalin, control group:refractive cataract surgery with topical mydriatics

    Drug: adrenalin

Interventions

  • adrenalin 0.01%

    Also known as: adrenaline hydrochloride

06

What researchers measure

Primary outcomes

  1. Pupil size after intracameral adrenaline

    We would like to evaluate Pupil size dilated with intracameral adrenaline 0.01%

    Time frame: 1day

Secondary outcomes

  1. endothelial cell count

    we would like to evaluate the endothelial cell count 1 month after surgery

    Time frame: 1month

07

Study locations

1 site
  • Wenzhou Medical College
    Wenzhou, Zhejiang 325000, China
08

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Dec 2010, a primary completion of Dec 2011 and a completion of Dec 2011. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 20, 2010
First posted
Dec 22, 2010
Start
Dec 2010
Primary completionActual
Dec 2011
CompletionActual
Dec 2011
Last update
Jul 6, 2012
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 6, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01264653
Lead sponsor
Wenzhou Medical University
Responsible party
A-Yong Yu (A-Yong Yu, Wenzhou Medical University) — Principal investigator
First posted
Dec 22, 2010
Start date
Dec 2010
Primary completion
Dec 2011
Completion
Dec 2011
Last update
Jul 6, 2012

Study contacts

Ayong Yu
study director · Wenzhou Medical University

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2012. You cannot join it, but the record below documents what was studied.

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Discussion

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Studies of the drug tested here: Epinephrine

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