An interventional study of Gradual weaning from Nasal CPAP in preterm neonates in Preterm Neonates, sponsored by Maimonides Medical Center. Completed at 1 site in United States. Open to participants aged 24 Weeks to 32 Weeks. Per ClinicalTrials.gov, last updated 2012-10-24.
Sponsored by Maimonides Medical Center · Not applicable, Interventional, and Treatment
To compare the 2 methods of weaning of nasal CPAP in premature babies born at 32 weeks or less
Objective: To study the weight and the post menstrual age (PMA) at the time of nasal CPAP (NCPAP) wean utilizing the method of sudden wean as compared to gradual wean. . Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age (GA) \<32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared.
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All babies born with GA \<32 weeks admitted to the neonatal intensive care units at the Maimonides Infant and Children's Hospital, between 1st January 2008 and 31st March 2009 and required to be on NCPAP for longer than 48 hours.-
Exclusion Criteria:
Those with severe congenital anomalies and chromosomal defects including congenital heart disease and neurological malformations, chest wall or airway abnormalities and lung hypoplasia, were excluded from the cohort
Nasal CPAP for gradual wean group it was cycled off for 3 hours alternating with 3 hours on for first 48 hours, if successful the cycle was extended to 6 hours off and 3 hours on for the next 48 hours. If the baby tolerated this regime the prongs were removed and CPAP was kept off.
Procedure: Gradual weaning from Nasal CPAP in preterm neonates
Usual practice to wean the preterm neonates from nasal CPAP
Nasal CPAP for gradual wean group it was cycled off for 3 hours alternating with 3 hours on for first 48 hours, if successful the cycle was extended to 6 hours off and 3 hours on for the next 48 hours. If the baby tolerated this regime the prongs were removed and CPAP was kept off.
Also known as: Nasal CPAP, Weaning, Preterm neonates
Weight when preterm neonates could come off nasal CPAP
Weight when preterm neonates could come off nasal CPAP
Time frame: During the initial NICU stay
Post-menstrual age when preterm neonates could come off nasal CPAP
Post-menstrual age when preterm neonates could come off nasal CPAP
Time frame: During the initial NICU stay
Weights when the neonates could come off oxygen
Weights when the neonates could come off oxygen
Time frame: During the initial NICU stay
length of stay in the hospital
length of stay in the hospital
Time frame: During the initial NICU stay
Post-menstrual age when preterm neonates could come off oxygen
Post-menstrual age when preterm neonates could come off oxygen
Time frame: During the initial NICU stay
This study is completed, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.
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Maimonides Medical Center