An observational study in Osteopetrosis, sponsored by Odense University Hospital. Completed at 1 site in Denmark. Open to participants aged 8 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-09-10.
Sponsored by Odense University Hospital · Observational
The aim of the study is to describe patients with a high bone mass phenotype due to a mutation in the low density lipoprotein l receptor 5 gene (LRP5) and compare them with age and sex matched controls. Moreover, bone density and microarchitecture as well as markers of bone metabolism are evaluated
Cases and controls are closely matched on age and sex and evaluated cross-sectionally.
Dual x-ray absorptiometry (DXA) and high resolution peripheral quantitative computed tomography (HR-pQCT) are used in order to evaluate bone density as well as microarchitecture. Bone turnover markers and body composition are also measured.
22 studies on the registry are indexed under Osteopetrosis; 4 are open to participants now.
Browse Osteopetrosis studies →Odense University Hospital is the lead sponsor of 479 studies on the registry; 110 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Case-control study on almost 40 individuals
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients known to have a mutation in Lrp5 known to be causing a high bone mass phenotype
Bone microarchitecture as assessed by high resolution quantitative computed tomography (HR-pQCT)
HR-pQCT is used to evaluate bone microarchitecture, i.e. bone trabeculae, cortical thickness and trabecular number. Aim is to test if the microarchitecture of these patients are different that observed in normal controls
Time frame: 12 weeks
Changes in bone turnover markers
Markers of bone resorption and formation are investigated.
Time frame: 12 weeks
Bone mineral density
DXA is used to evaluate bone mineral density at total hip, spine, whole body and forearm.
Time frame: 12 weeks
This study is completed, as verified in Aug 2010. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.