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CompletedNCT01180010Updated Dec 29, 2016

Low Dose Chest Computed Tomography (CT) Screening

An observational study in Hodgkin's Lymphoma, sponsored by University Health Network, Toronto. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-12-29.

Sponsored by University Health Network, Toronto · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
31
Ages
18 Years and older
Sex
All
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Study summary

This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner. Depending on the findings of the initial CT scan, we will then either repeat the scan in 1 year, or if indicated, send you for further scans or a biopsy. The information collected in this study will help researchers and clinicians in providing more concrete recommendations and screening guidelines for future survivors of Hodgkin's disease who have had similar exposures to radiation and/or chemotherapy and smoking.

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Conditions studied

  • Hodgkin's Lymphoma

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Keywords

  • Hodgkin's Lymphoma
  • Lung Cancer
  • Lung Nodule
  • CT scan
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In context

Hodgkin Disease

885 studies on the registry are indexed under Hodgkin Disease; 132 are open to participants now.

This study's enrollment of 31 is below the median of 130 across 119 observational studies indexed under Hodgkin Disease.

Browse Hodgkin Disease studies →

Lead sponsor

University Health Network, Toronto is the lead sponsor of 1,411 studies on the registry; 292 are open to participants now.

Of its 17 completed or terminated interventional studies of FDA-regulated products, 3 (18%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients treated for Hodgkin's Lymphoma

Inclusion criteria

  1. 5 years or longer from initial Hodgkin's disease diagnosis
  2. Current age 18 or older
  3. Received mediastinal irradiation and/or alkylating-agent based chemotherapy
  4. Smoking history of 10-pack years or more, or current smoker

Exclusion criteria

Exclusion Criteria:

  1. Patients with a history of lung cancer
  2. Patients currently receiving treatment for another cancer diagnosis (patients with another cancer, but currently disease-free and not receiving treatment are eligible)
  3. Patients with known diagnosis of any metastatic cancer
  4. Pregnant women. Female patients must: be at least one year post-menopausal, have had a hysterectomy, or have a serum pregnancy test to confirm that they are not pregnant. These measures must be taken in order to avoid doing a CT scan of a pregnant woman.
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
31 participants (actual)

Interventions

  • ProcedureLow Dose CT

    A chest CT uses special radiographic equipment using x-rays to capture images of the chest, and with the aid of a computer, processes the images to create cross-sectional pictures or "slices" of the areas of interest. The images can then be printed out or examined on a monitor. The CT scanner is a large unit with a hole running directly through its center, giving the appearance of a doughnut. During the scanning, patients will lie flat on their back on a table, and they are periodically asked to hold their breath. The table will first move through the scanner to determine the correct starting position. The rest of the scans are made as the table moves more slowly through the cavity in the scanner.

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What researchers measure

Primary outcomes

  1. Lung cancer detection rate using chest CT screening in patients at increased risk of lung cancer after Hodgkin's disease therapy.

    Time frame: 5 years

  2. False-positive rates of using chest CT for lung cancer screening in this population.

    Time frame: 5 years

Secondary outcomes

  1. The stage distribution, clinical characteristics and pathologic features of the detected lung cancer

    Time frame: 5 years

  2. The treatment and treatment outcome of lung cancer after Hodgkin's disease in a cohort of patients undergoing routine chest CT screening

    Time frame: 5 years

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Study locations

1 site
  • University Health Network, Princess Margaret Hospital
    Toronto, Ontario M5G 2M9, Canada
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 29, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01180010
Lead sponsor
University Health Network, Toronto
Collaborators
Princess Margaret Hospital, Canada
Responsible party
Sponsor
First posted
Aug 11, 2010
Start date
Aug 2010
Primary completion
Sep 2015
Completion
Sep 2015
Last update
Dec 29, 2016

Study contacts

David Hodgson, MD
principal investigator · University Health Network, Princess Margaret Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2016. You cannot join it, but the record below documents what was studied.

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