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Status unknownNCT01174966ICUPtO2OCTUpdated Aug 4, 2010

Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients

An observational study in Sepsis and Shock, sponsored by Peking Union Medical College Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 95 Years. Per ClinicalTrials.gov, last updated 2010-08-04.

Sponsored by Peking Union Medical College Hospital · Observational

The sponsor has not verified this record recently (last verified Aug 2010), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
60
Ages
18 Years to 95 Years
Sex
All
01

Study summary

The lack of subcutaneous partial pressure of oxygen (PO2) rise in response to high fraction of inspired oxygen (FiO2), called the "oxygen challenge test (OCT)", was associated with higher morbidity and mortality in human subjects. Patients had negative O2 challenge test results, indicating that flow-dependent O2 consumption might have been present. Recent reports using the noninvasive transcutaneous PO2 (PtO2) and transcutaneous partial pressure of carbon dioxide probes have observed a relationship between low oxygen challenge test values to mortality and organ failure. The OCT values provides an accessible noninvasive method of detecting early shock.

To date,these studies of OCT in the ICU patients are rarely. No one has quantified OCT to CI, DO2I、ScvO2.

This study explored:

  1. relationship between patient factors, hemodynamic variables, PtO2, and OCT to mortality;
  2. relationship between PtO2 index, tissue oxygen index, oxygen Challenge index to CI, DO2, ScvO2.
Read the detailed description

PtO2 index = PtO2/PaO2；tissue oxygen index=PtO2/FiO2；

5min OCT value = challenged 5minPtO2 - PtO2baseline；

10min OCT value= challenged 10minPtO2- PtO2baseline；

oxygen challenge index = （10minPtO2- PtO2baseline）/(10minPaO2-PaO2baseline)

02

Conditions studied

  • Sepsis
  • Shock

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Keywords

  • oxygen challenge test
  • shock
  • mortality
  • Oxygen Delivery Index
  • cardiac output index
03

In context

Shock

916 studies on the registry are indexed under Shock; 176 are open to participants now.

This study's planned enrollment of 60 is below the median of 91 across 346 observational studies indexed under Shock.

Browse Shock studies →

Lead sponsor

Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 95 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

The subjects were sequentially admitted to the Department of Critical Care department of Peking Union Medical College Hospital from sept. of 2009 till the end of this study.

Inclusion criteria

  • 18 years of age or older
  • Requiring a artery catheters, and pulmonary artery catheters or PiCCO-plus or central venous catheters
  • FiO2\<80% and SpO2>92%
  • Consent informed

Exclusion criteria

Exclusion Criteria:

  • Not expected to live
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
60 participants (estimated)

Groups and cohorts

  • Survivor Nonsurvivor
06

What researchers measure

Primary outcomes

  1. ICU mortality

    Time frame: 28 day after enrollmented

Secondary outcomes

  1. hospital mortality

    Time frame: 28 day after enrollmented

07

Study locations

1 of 1 sites recruiting
  • Peking Union Medical College Hospital
    Beijing, Beijing 100730, China
    Recruiting
08

References and documents

Publications

  • Yu M, Morita SY, Daniel SR, Chapital A, Waxman K, Severino R. Transcutaneous pressure of oxygen: a noninvasive and early detector of peripheral shock and outcome. Shock. 2006 Nov;26(5):450-6. doi: 10.1097/01.shk.0000228798.18174.6a. PubMed 17047514 ↗
  • Yu M, Chapital A, Ho HC, Wang J, Takanishi D Jr. A prospective randomized trial comparing oxygen delivery versus transcutaneous pressure of oxygen values as resuscitative goals. Shock. 2007 Jun;27(6):615-22. doi: 10.1097/shk.0b013e31802f0295. PubMed 17505300 ↗
  • Jonsson K, Jensen JA, Goodson WH 3rd, West JM, Hunt TK. Assessment of perfusion in postoperative patients using tissue oxygen measurements. Br J Surg. 1987 Apr;74(4):263-7. doi: 10.1002/bjs.1800740413. PubMed 3580798 ↗
  • Goeckenjan G, Strasser K. Relation of transcutaneous to arterial pO2 in hypoxaemia, normoxaemia and hyperoxaemia. Investigations in adults with normal circulation and in patients with circulatory insufficiency. Biotelemetry. 1977;4(2):77-87. PubMed 610773 ↗
  • Reed RL 2nd, Maier RV, Landicho D, Kenny MA, Carrico CJ. Correlation of hemodynamic variables with transcutaneous PO2 measurements in critically ill adult patients. J Trauma. 1985 Nov;25(11):1045-53. PubMed 4057292 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 4, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01174966
Lead sponsor
Peking Union Medical College Hospital
First posted
Aug 4, 2010
Start date
Sep 2009
Primary completion
Oct 2010 (estimated)
Completion
Oct 2010 (estimated)
Last update
Aug 4, 2010

Study contacts

dawei liu, MD
Contact
dwliu98@yahoo.com
010-65296091
huaiwu he
Contact
tjmuhhw@hotmail.com
010-65296094
dawei liu, MD
principal investigator · Peking Union Medical College Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2010. You cannot join it, but the record below documents what was studied.

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