A Phase 1 interventional study of Peanuts and Glucose and whipping cream in Cardiovascular Disease, sponsored by Penn State University. Completed at 1 site in United States. Open to male participants aged 30 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-08-21.
Sponsored by Penn State University · Phase 1, Interventional, and Treatment
This pilot study will investigate the effects of acute peanut consumption on markers of inflammation, triglycerides and glucose. The hypothesis is that a high glucose/SFA meal will increase postprandial production of the inflammatory marker, C-reactive protein (CRP), and that the addition of peanuts to the control meal will reduce the production of CRP, as well as triglycerides and glucose.
Previous research has demonstrated that a single meal high in saturated fatty acids (SFA) and glucose can induce increases in IL-6, TNF-α and CRP in abdominally obese and diabetic subjects. As over two-thirds of the U.S. population is overweight or obese, it is important to identify foods that can attenuate postprandial increases in lipids, glucose and inflammation in this population. Therefore, the purpose of the pilot study is to determine whether a high SFA / high glucose control meal will induce an acute inflammatory response in overweight individuals, and whether the addition of peanuts to this meal will ameliorate this response. To ensure that these effects are due to peanuts, and not to the increase in total fat, we will compare this response to another test meal that includes an oil blend with a similar fatty acid composition to peanuts.
4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.
This study's enrollment of 6 is below the median of 100 across 2,738 interventional studies indexed under Cardiovascular Diseases.
Browse Cardiovascular Diseases studies →Penn State University is the lead sponsor of 263 studies on the registry; 51 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 10 (77%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Shake containing heavy whipping cream, glucose and chocolate syrup
Dietary Supplement: Glucose and whipping cream
Shake containing control (whipping cream, glucose and chocolate syrup) + 3oz of peanuts
Dietary Supplement: Peanuts
Shake containing control (heavy whipping cream, glucose and chocolate syrup) + oil blend (equivalent to fatty acids provided in 3oz peanuts)
Dietary Supplement: Oil Blend
Shake containing 3.0oz of peanuts (including skin) + control (heavy whipping cream, glucose and chocolate syrup)
An oral liquid glucose (75g) and fat (high saturated fat from 60g heavy whipping cream) load. Chocolate syrup is added for flavor.
Shake containing an oil blend (sunflower, sesame, olive and palm oils) + control (heavy whipping cream, glucose and chocolate syrup). The amount of oil added to the control will provide an equivalent amount of fat to that provided in 3 oz (85g) of peanuts
Serum C-reactive protein
Time frame: 0min
Serum C-reactive protein
Time frame: 60 min
Serum C-reactive protein
Time frame: 120 min
Serum C-reactive protein
Time frame: 240 min
Serum Glucose
Time frame: 0 min
Serum Insulin
Time frame: 0 min
Serum Triglycerides
Time frame: 0 min
Serum Glucose
Time frame: 60 min
Serum Glucose
Time frame: 120 min
Serum Glucose
Time frame: 240 min
Serum Insulin
Time frame: 60 min
Serum Insulin
Time frame: 120 min
Serum Insulin
Time frame: 240 min
Serum Triglycerides
Time frame: 60 min
Serum Triglycerides
Time frame: 120 min
Serum Triglycerides
Time frame: 240 min
This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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