An observational study in Smoking and Cardiac Diseases, sponsored by Medical University of Vienna. Completed at 1 site in Austria. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-05-20.
Sponsored by Medical University of Vienna · Observational
Endostatin, a 20-kDa cleavage product of collagen XVIII, is a component of the extracellular matrix expressed in the basement membrane. As a potent inhibitor of angiogenesis, endostatin induces endothelial cell apoptosis and diminishes cell migration, adhesion and proliferation.
Endostatin may stop the progression of atherosclerosis. Atherosclerotic heart disease involves unwanted tissue growth. By cutting off the blood supply from a plaque the likelihood of plaque rupture may eventually be reduced. Recent data indicates that the loss of collagen XVIII/endostatin is related to the enhancement of neo-vascularization and vascular permeability in atherosclerosis. Plaque neo-vascularization strongly correlates with the regional content of inflammatory cells. Furthermore, increased vascular permeability enhances lipid accumulation in the vessel walls, hence increasing foam cells.
Therapeutic angiogenesis is a most promising strategy for the treatment of myocardial infarction. However, it remains unknown if and how endogenous angiogenesis inhibitors, such as endostatin, regulate angiogenesis in myocardial infarction. Rat models showed that after myocardial infarction endostatin neutralization displayed adverse left ventricular remodeling and severe heart failure compared with controls. Although angiogenesis was increased, tissue remodeling and interstitial fibrosis were further exaggerated in post-myocardial infarction hearts by endostatin neutralization.
However, several studies suggest that endostatin may locally modulate coronary collateral formation by inhibiting collateral vessel formation in patients with ischemic heart disease.
During treadmill exercise tests in healthy volunteers a significant increase in circulating endostatin levels can be observed. Exercise induces angiogenesis in cardiac and skeletal muscles by decreasing endostatin in the muscle tissues to increase blood flow to these metabolically active tissues. Thereby endostatin is released into the general circulation.
In summary, endostatin might be a new weapon to fight against atherosclerotic progression by inhibiting neo-vascularization of atherosclerotic plaques.
3,639 studies on the registry are indexed under Heart Diseases; 461 are open to participants now.
This study's enrollment of 240 is below the median of 294 across 1,241 observational studies indexed under Heart Diseases.
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200 patients, divided into sub-groups, always both genders will be tested for different conditions (smoking, age, CMP, CHD,...)
Exclusion Criteria:
20 healthy females, aged between 18 and 35 years
20 healthy males, aged between 18 and 35 years
20 healthy smokers, aged between 45 and 75 years
20 healthy non-smokers, aged between 45 and 75 years
20 healthy female smokers, aged between 18 and 35 years
20 healthy male smokers, aged between 18 and 35 years
20 healthy postmenopausal women
20 female patients suffering from cardiomyopathy (ischemic or dilating)
20 male patients suffering from cardiomyopathy (ischemic or dilating)
30 female patients suffering from cardiac heart disease, before aorto-coronary bypass surgery (and after)
30 male patients suffering from cardiac heart disease, before aorto-coronary bypass surgery (and after)
20 male athlets
20 female athlets
Endostatin
baseline sample will be drawn at rest; a second sample will be drawn 5 minutes after each individual reaches its peak workload (average time 10 minutes)
Time frame: baseline/maximum
catecholamine
baseline sample will be drawn at rest
Time frame: baseline
hemodynamic parameters
heart rate and blood pressure behavior will be monitored throughout the entire bicycle stress test
Time frame: baseline
catecholamine
a second sample will be drawn 5 minutes after each individual reaches its peak workload (average time 10 minutes)
Time frame: day 1
This study is completed, as verified in May 2014. You cannot join it, but the record below documents what was studied.
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Medical University of Vienna