An observational study in Digestive System Diseases, sponsored by Chinese PLA General Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-11-23.
Sponsored by Chinese PLA General Hospital · Observational
Confocal laser endomicroscopy (CLE) is a newly endoscopic device that enables microscopic view of the digestive tract. The purpose of this study is to determine if confocal laser endomicroscopy can improve detection of digestive disease include inflammation, dysplasia, and early cancer, and if confocal laser endomicroscopy has competitive advantage, compared with other device such as Narrow Band Imaging and Autofluoresecence Imaging.
Advances in endoscopy have led to imagining of the details of digestive mucosa. Novel techniques such as Narrow Band Imaging (NBI) assisted magnification endoscopy, Auto Fluorescence Imaging (AFI) or confocal laser endomicroscopy could, however, improve the endoscopic detection.In this research we describe the combined use of these three techniques in patients with digestive disease.
613 studies on the registry are indexed under Digestive System Diseases; 117 are open to participants now.
This study's planned enrollment of 500 is above the median of 272 across 193 observational studies indexed under Digestive System Diseases.
Browse Digestive System Diseases studies →Chinese PLA General Hospital is the lead sponsor of 558 studies on the registry; 202 are open to participants now.
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Patients of a tertiary referral hospital
Exclusion Criteria:
The investigators cases are subjects with confirmed digestive diseases.
Device: Confocal Laser Endomicroscopy (Pentax/Optiscan) · Device: Narrow Band Imaging/Auto Fluorescence Imaging (Olympus)
Healthy individuals aged between 18 and 90 years who are asymptomatic for digestive diseases.
Device: Confocal Laser Endomicroscopy (Pentax/Optiscan) · Device: Narrow Band Imaging/Auto Fluorescence Imaging (Olympus)
Confocal laser endomicroscopy is performed using the Pentax/Optiscan confocal endomicroscopy and 5 ml of 10% intravenous fluorescein sodium. Photos of magnified images of the digestive mucosa are taken during the procedure.
Also known as: Confocal endomicroscopy
NBI/AFI endoscope offers an alternative light source involve NBI and AFI to view digestive mucosa in real time.
Also known as: Narrow Band Imaging(NBI), Auto Fluorescence Imaging(AFI)
Diagnostic yield for neoplasia of CLE vs. standard endoscopy
Time frame: one year
Diagnostic yield for neoplasia of CLE vs. NBI/AFI
Time frame: one year
This study is status unknown, as verified in Jul 2010. You cannot join it, but the record below documents what was studied.
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Chinese PLA General Hospital