An interventional study of Esophagectomy and Neoadjuvant chemoradiation followed by surgery in Esophageal Neoplasms, sponsored by All India Institute of Medical Sciences, New Delhi. Status unknown at 1 site in India. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2010-07-12.
Sponsored by All India Institute of Medical Sciences, New Delhi · Not applicable, Interventional, and Treatment
Carcinoma of the esophagus is the among the most common cancers in Indian population. While adenocarcinoma is more common in western countries, in India squamous cell carcinoma is the more frequent form. Surgery is the standard treatment in resectable lesions, but survival is poor. Adjuvant and neoadjuvant treatment therapy is used with an aim to improve the results. Though few randomized trials have addressed the issue of neoadjuvant chemoradiotherapy, the methodology was inhomogeneous and the populations studied were different. The investigators will be conducting a randomized controlled trial in patients with squamous cell carcinoma of the esophagus. Preoperative chemoradiation followed by surgery will be compared with surgery alone.
6,741 studies on the registry are indexed under Carcinoma; 1,161 are open to participants now.
This study's planned enrollment of 100 is above the median of 45 across 5,170 interventional studies indexed under Carcinoma.
Browse Carcinoma studies →All India Institute of Medical Sciences, New Delhi is the lead sponsor of 146 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Comorbid conditions which would preclude oesophagectomy
Procedure: Esophagectomy
Procedure: Neoadjuvant chemoradiation followed by surgery
Patient with squamous cell carcinoma of esophagus will be treated with surgery alone
Patient with squamous cell carcinoma of esophagus will be treated by neoadjuvant chemoradiation followed by surgery
Resectability rate
To compare the resectability rate of carcinoma esophagus between patients randomized to surgery alone and neoadjuvant chemoradiation followed by surgery
Time frame: 2 years
postoperative morbidity
To compare the postoperative morbidity between patients of carcinoma esophagus randomized to surgery alone versus chemoradiation followed by surgery
Time frame: 2 Years
operative mortality
To compare the operative mortality between patients randomized to surgery alone and neoadjuvant chemoradiation followed by surgery.
Time frame: 2 Years
Early disease control
To compare the early disease control in patients randomized to receive either neoadjuvant chemoradiation and surgery or surgery alone.
Time frame: 2 years
Treatment toxicity
This study will also assess the treatment toxicity of preoperative chemoradiation
Time frame: 2 years
This study is status unknown, as verified in Jun 2010. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
All India Institute of Medical Sciences, New Delhi