An observational study in Hepatitis C, Chronic, sponsored by Charles University, Czech Republic. Completed at 1 site in Czechia. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-08-07.
Sponsored by Charles University, Czech Republic · Observational
In this project, the investigators aim to study the role of biliverdin reductase A (BLVRA) in HCV infected patients prior and during/after standard antiviral therapy in association with viral clearance, disease progression and treatment response and in comparison with healthy subjects.
1,090 studies on the registry are indexed under Hepatitis C, Chronic; 9 are open to participants now.
This study's enrollment of 113 is below the median of 250 across 247 observational studies indexed under Hepatitis C, Chronic.
Browse Hepatitis C, Chronic studies →Charles University, Czech Republic is the lead sponsor of 227 studies on the registry; 76 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Estimated enrollment: BLVRA expression study: 50 - 100 HCV patients 50 healthy volunteers Polymorphisms of BLVRA study: 300 HCV patients
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BLVRA expression study
BLVRA genetic polymorphisms study
Exclusion Criteria:
The study was performed on therapeutically naïve patients with chronic HCV infection. Patients with positivity of anti-HCV antibodies, and detectable HCV RNA in serum for at least 6 months, were included in the study.
To assess differences in BLVRA expression in the liver and PBMC in HCV infected patients in responders and non-responders to standard antiviral therapy.
Time frame: 72 weeks
To analyze the association of genetic polymorphisms of BLVRA with disease progression and treatment response in HCV infected patients.
Time frame: 3 years
This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.
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Charles University, Czech Republic →