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CompletedNCT01090375Updated Mar 19, 2010

Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

An Early Phase 1 interventional study of Exercise and Non Exercise in Osteoarthritis and Exercise, sponsored by Bispebjerg Hospital. Completed. Open to female participants aged 55 Years to 75 Years. Per ClinicalTrials.gov, last updated 2010-03-19.

Sponsored by Bispebjerg Hospital · Early Phase 1, Interventional, and Basic science

Phase
Early Phase 1
Study type
Interventional
Ages
55 Years to 75 Years
Sex
Female
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Study summary

In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

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Conditions studied

  • Osteoarthritis
  • Exercise

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Keywords

  • osteoarthritis
  • biochemical markers
  • cartilage
  • inflammation
  • microdialysis
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In context

Osteoarthritis

4,399 studies on the registry are indexed under Osteoarthritis; 583 are open to participants now.

Browse Osteoarthritis studies →

Lead sponsor

Bispebjerg Hospital is the lead sponsor of 281 studies on the registry; 29 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
55 Years to 75 Years
Sexes eligible
Female

Inclusion criteria

  • verified osteoarthritis (x-ray)of the knee, female,

Exclusion criteria

Exclusion Criteria:

  • dementia, inflammatory diseases, regular pain medication
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Study design

Phase
Early Phase 1
Primary purpose
Basic science
Intervention model
Parallel assignment

Study arms

  • Experimental
    Exercise

    Other: Exercise

  • Placebo comparator
    Non Exercise

    Other: Non Exercise

Interventions

  • OtherExercise
  • OtherNon Exercise
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Study locations

No study locations are listed for this record.

07

References and documents

Publications

  • Helmark IC, Mikkelsen UR, Borglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Res Ther. 2010;12(4):R126. doi: 10.1186/ar3064. Epub 2010 Jul 1. PubMed 20594330 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 19, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01090375
Lead sponsor
Bispebjerg Hospital
Collaborators
The Danish Rheumatism Association, Danish Ministry of Health, Internal Affairs, Danish National Research Council, The Danish Medical Research Council
First posted
Mar 19, 2010
Start date
Aug 2008
Primary completion
Mar 2009
Last update
Mar 19, 2010

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.

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