An observational study in Cancer Survivor, Chronic Myeloproliferative Disorders and Leukemia, sponsored by Vanderbilt University. Terminated at 1 site in United States. Open to male participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2014-12-10.
Sponsored by Vanderbilt University · Observational
RATIONALE: Studying samples of semen from cancer survivors in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This phase I research study is looking at the presence of donor-derived DNA in semen samples form cancer survivors who underwent donor stem cell transplant.
OBJECTIVES:
OUTLINE: Semen samples are collected and assessed by flow cytometry and PCR. DNA samples are compared to previously analyzed DNA extracted from survivor and donor. Samples are also analyzed for sperm concentration, motility, morphology, and viability.
5,579 studies on the registry are indexed under Lymphoma; 825 are open to participants now.
This study's enrollment of 24 is below the median of 136 across 625 observational studies indexed under Lymphoma.
Browse Lymphoma studies →Vanderbilt University is the lead sponsor of 508 studies on the registry; 19 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 5 (71%) have results posted.
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Males over the age of 18 who have a history of allogeneic stem cell transplant >365 days ago with history of full donor engraftment, whose disease is in remission,
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Genetic: DNA analysis · Genetic: polymerase chain reaction · Other: flow cytometry · Other: laboratory biomarker analysis
DNA analysis will be performed on samples collected.
A polymerase chain reaction (PCR) assessment will be done on the samples collected.
Flow cytometry will be done on the samples collected.
Laboratory biomarker analysis will be performed on the samples collected.
Presence of donor-derived DNA in semen samples of male survivors of allogeneic hematopoietic stem cell transplantation
Time frame: end of study
This study is terminated, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
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Vanderbilt University