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CompletedNCT01077336Updated Jul 16, 2014

Clinical Outcomes in Candidemia Patients Based on in Vitro Susceptibility

An observational study in Blood Stream Infections and Candida, sponsored by University of Houston. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2014-07-16.

Sponsored by University of Houston · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
450
Ages
18 Years and older
Sex
All
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Study summary

Susceptibility testing is commonly employed in patients with bacterial infections in order to guide rational use of antibiotics; however, the use of antifungal susceptibility testing is limited due to lack of availability, costs, and delays in receiving results. The goals of antifungal susceptibility testing should mirror those of antibacterial susceptibility testing: to predict clinical response or failure. Additionally, susceptibility reports should be used as a guide for physicians when transitioning patients from parenteral to oral antifungal agents. Currently, it is unknown whether antifungal susceptibility testing impacts treatment decisions in hospitals that routinely perform Candida susceptibility testing. The purpose of this study is to evaluate the changes in antifungal treatment based on in vitro susceptibility reports and how these decisions affect mortality, recurrence of infection, and length of hospital stay in candidemia patients.

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Conditions studied

  • Blood Stream Infections
  • Candida

Keywords

  • susceptibility testing
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In context

Candidemia

65 studies on the registry are indexed under Candidemia; 4 are open to participants now.

This study's enrollment of 450 is above the median of 250 across 25 observational studies indexed under Candidemia.

Browse Candidemia studies →

Lead sponsor

University of Houston is the lead sponsor of 101 studies on the registry; 17 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 3 (33%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

This will be a retrospective cohort study of 400 hospitalized patients with bloodstream infections from January 2006 to January 2009 due to Candida species

Inclusion criteria

  • Hospitalized patients with bloodstream infections due to Candida species

Exclusion criteria

Exclusion Criteria:

  • Patients will be excluded from this study if their medical charts contain incomplete outcome or susceptibility data. Patients treated empirically or definitively with amphotericin-based products will also be excluded
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
450 participants (actual)

Groups and cohorts

  • Hospitalized patients with candidemia
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What researchers measure

Primary outcomes

  1. Assess empiric choice of antifungal therapy in hospitalized patients with candidemia.

    Time frame: Assessments made for 30-days after postivie blood culture

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Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 16, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01077336
Lead sponsor
University of Houston
Collaborators
Merck Sharp & Dohme LLC
Responsible party
Kevin W. Garey (Professor and Chair, University of Houston) — Principal investigator
First posted
Mar 1, 2010
Start date
Jan 2010
Primary completion
Jan 2011
Completion
Jan 2011
Last update
Jul 16, 2014

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2014. You cannot join it, but the record below documents what was studied.

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