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CompletedNCT01076608DETECTUpdated Feb 26, 2010

DETECT-Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment

An observational study in Cardiovascular Diseases, sponsored by Technische Universität Dresden. Completed. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-02-26.

Sponsored by Technische Universität Dresden · Observational

Study type
Observational
Model
Ecologic or community
Time perspective
Prospective
Enrollment
55,518
Ages
18 Years and older
Sex
All
01

Study summary

Cardiovascular diseases are, along with cancer, the most frequent causes for mortality and morbidity in the industrialized nations. Numerous clinical efficient approaches to reduce the known risk factors have been introduced in clinical routine care; yet with quite limited success, e.g. modification of behavioral risk factors, drug treatment and the combination of both. On the population level only marginal changes have been demonstrated, i.e. the mortality from myocardial infarction and stroke remains high.

To answer questions about underlying factors, for this unsatisfactory status, we might profit tremendously from studies that examine the situation, where treatment of patients most frequently take place: in primary care. This approach pays attention to the General Practitioner's (GP) in their gate keeping function in health care. Information from primary care in particular is largely lacking as recently stated by the "Sachverständigenrat für die konzertierte Aktion im Gesundheitswesen" in 2001. The DETECT study has been designed to address these critical issues.

On 16th and 18th September 2003, 3,188 GPs completed a standardised assessment of the diagnostic and therapeutic profile of 55,518 unselected consecutive patients. All patients completed a questionnaire on their demographic data, their complaints, their illness history, their knowledge about selected diseases and their attitude towards those. A sub sample of 7,519 patients additionally attended a standardized laboratory screening program. In this screening the focus was on blood constituents connected with cardiovascular diseases and diabetes, including e. g. cholesterol, lipoproteins, triglycerides and HbA1c. These patients were assessed a second time in the follow up period after one year in 2004 and for a final time after completion of the five-year follow-up period.

Read the detailed description

What kind of information will DETECT provide?

I. From the cross sectional part (descriptive epidemiological part on 16th/18th September 2003)

  • Frequency, characteristics and severity of cardiovascular diseases, selected associated metabolic syndromes and atherosclerotic diseases and syndromes
  • Identification and determination of the proportion of patients with high-risk constellations (e.g., post myocardial infarction, associated morbidities, laboratory measures)
  • Rates of General Practitioners recognition, diagnostic and therapeutic profiles
  • Assessment of quality of care (comparison with guidelines)
  • Indicators of undertreatment, overtreatment and inadequate treatment

II. From the longitudinal part

Changes of laboratory parameters and diagnoses after one and five years, in relation to:

  • Initial diagnostic and therapeutic status
  • Selected intervention criteria
  • Composition of risk indicators, and comparison with existing indices (PROCAM, Framingham, Score etc.)
  • Measurement of frequency and point of critical outcomes e.g., myocardial infarction, associated morbidity, hospitalisation, critical medical interventions
  • Significance of established and "new" cardiovascular risk factors
  • Prognostic value of biomarkers for risk stratification
02

Conditions studied

  • Cardiovascular Diseases

Keywords

  • primary care patients
03

In context

Cardiovascular Diseases

4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.

This study's enrollment of 55,518 is above the median of 573 across 1,485 observational studies indexed under Cardiovascular Diseases.

Browse Cardiovascular Diseases studies →

Lead sponsor

Technische Universität Dresden is the lead sponsor of 237 studies on the registry; 45 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Representative random sample of 3188 General Practitioners in Germany (general practitioners and internists serving as GPs), who included patients:

  • Main study: 55,518 (unselected consecutive)
  • Longitudinal observation study in a random subset of 7519 patients

Inclusion criteria

  • unselected primary care patients

Exclusion criteria

Exclusion Criteria:

  • none
05

Study design

Observational model
Ecologic or community
Time perspective
Prospective
Enrollment
55,518 participants (actual)
Biospecimen retention
Samples without dna
06

Study locations

No study locations are listed for this record.

07

References and documents

Publications

  • Wittchen HU, Glaesmer H, Marz W, Stalla G, Lehnert H, Zeiher AM, Silber S, Koch U, Bohler S, Pittrow D, Ruf G; DETECT-Study Group. Cardiovascular risk factors in primary care: methods and baseline prevalence rates--the DETECT program. Curr Med Res Opin. 2005 Apr;21(4):619-30. doi: 10.1185/030079905X38187. PubMed 15899112 ↗

Related links

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 26, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01076608
Lead sponsor
Technische Universität Dresden
Collaborators
Johann Wolfgang Goethe University Hospital, Max-Planck-Institute of Psychiatry, University of Magdeburg, Medical University of Graz, Universitätsklinikum Hamburg-Eppendorf
First posted
Feb 26, 2010
Start date
Sep 2003
Primary completion
Sep 2008
Completion
Dec 2008
Last update
Feb 26, 2010

Study contacts

Hans-Ullrich Wittchen, Prof. Dr.
principal investigator · Director of the Institute of Clinical Psychology and Psychotherapy at the Technical University of Dresden

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2010. You cannot join it, but the record below documents what was studied.

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