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CompletedNCT01039415Updated Oct 31, 2016

Attempts to Stop/Reduce Marijuana Among Dependent Users

An observational study in Marijuana Abuse and Marijuana Dependence, sponsored by University of Vermont. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-10-31.

Sponsored by University of Vermont · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
234
Ages
18 Years and older
Sex
All
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Study summary

The purpose of the study is to determine why and how marijuana users stop or reduce their marijuana use.

Read the detailed description

The major aim of this study is to provide a better understanding of attempts to stop or reduce marijuana use that can be used to develop better behavioral treatments for marijuana dependence. The application will focus on adult daily marijuana users who try to stop or reduce their marijuana use in a real-world setting. Although prospective, natural history studies describing attempts to stop or reduce alcohol, heroin and tobacco use have proved useful, we know of no such study among adult marijuana users. Two pilot studies will develop measures and assess compliance with our procedures. The main study will recruit up to 400 adult marijuana smokers with the goal of a sample size of 200 participants with adequate compliance. Participants will call an Interactive Voice Recording (IVR) system daily for 3 months to report marijuana use, quit/reduction attempts, and events that might increase or decrease the probability of initiating a quit/reduction attempt or the success of an attempt. Follow-up at 6 months will track recent marijuana and other drug use. Knowing what motivates marijuana users to try to stop or reduce, and knowing which strategies for stopping marijuana use are successful, can help develop treatments for marijuana dependence. For example, if stopping tobacco when trying to stop marijuana decreases the chance of stopping marijuana, then smoking cessation should be done after stopping marijuana. Or if reducing marijuana often leads to cessation, then convincing those not interested in quitting marijuana to first try reducing may be helpful.

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Conditions studied

  • Marijuana Abuse
  • Marijuana Dependence

Keywords

  • marijuana
  • marijuana abuse
  • marijuana dependence
  • cannabis
  • substance-related disorder
  • abstinence
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In context

Marijuana Abuse

530 studies on the registry are indexed under Marijuana Abuse; 114 are open to participants now.

This study's enrollment of 234 is above the median of 100 across 80 observational studies indexed under Marijuana Abuse.

Browse Marijuana Abuse studies →

Lead sponsor

University of Vermont is the lead sponsor of 221 studies on the registry; 27 are open to participants now.

Of its 17 completed or terminated interventional studies of FDA-regulated products, 9 (53%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

adults 18 and older

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • daily marijuana smokers for at least 1 year

Exclusion criteria

Exclusion Criteria:

  • pregnant women
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
234 participants (actual)
06

What researchers measure

Primary outcomes

  1. initiation of a quit or reduction attempt

    Time frame: during 3 months of monitoring

Secondary outcomes

  1. duration of a quit attempt

    Time frame: during the 3 months of monitoring

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Study locations

1 site
  • University of Vermont
    Burlington, Vermont 05401, United States
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References and documents

Publications

  • Hughes JR, Fingar JR, Budney AJ, Naud S, Helzer JE, Callas PW. Marijuana use and intoxication among daily users: an intensive longitudinal study. Addict Behav. 2014 Oct;39(10):1464-70. doi: 10.1016/j.addbeh.2014.05.024. Epub 2014 Jun 4. PubMed 24935797 ↗
  • Hughes JR, Naud S, Budney AJ, Fingar JR, Callas PW. Attempts to stop or reduce daily cannabis use: An intensive natural history study. Psychol Addict Behav. 2016 May;30(3):389-97. doi: 10.1037/adb0000155. Epub 2016 Feb 1. PubMed 26828641 ↗
  • Hughes JR, Naud S, Budney AJ, Fingar JR, Callas PW. Environmental cues and attempts to change in daily cannabis users: An intensive longitudinal study. Drug Alcohol Depend. 2016 Apr 1;161:15-20. doi: 10.1016/j.drugalcdep.2015.09.033. Epub 2016 Feb 6. PubMed 26872879 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 31, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01039415
Responsible party
John Hughes (Professor of psychiatry, University of Vermont) — Principal investigator
First posted
Dec 25, 2009
Start date
Jun 2010
Primary completion
Oct 2012
Completion
Oct 2012
Last update
Oct 31, 2016

Study contacts

John Hughes, MD
principal investigator · University of Vermont

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2016. You cannot join it, but the record below documents what was studied.

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