CompletedNCT01034293Updated Jul 23, 2010

Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning

An interventional study of low feeding frequency (3x) and High feeding frequency (14x) in Insulin and Glucose Metabolism, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-07-23.

Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Prevention

Phase: Not applicable
Study type: Interventional
Enrollment: 14
Allocation: Randomized
Ages: 18 Years to 35 Years
Sex: Male

Study summary

The purpose of this study is to determine the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning.

Conditions studied

Insulin
Glucose Metabolism

Browse trials for

Insulin Resistance 2,025

Keywords

feeding frequency
insulin metabolism
glucose metabolism
substrate partitioning

In context

Insulin Resistance

2,025 studies on the registry are indexed under Insulin Resistance; 308 are open to participants now.

This study's enrollment of 14 is below the median of 40 across 1,587 interventional studies indexed under Insulin Resistance.

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Lead sponsor

Maastricht University Medical Center is the lead sponsor of 852 studies on the registry; 116 are open to participants now.

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Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 35 Years
Sexes eligible: Male
Accepts healthy volunteers: Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

BMI: 18.5-25 kg/m2 (lean)
Gender: Male
Age: subjects has to be older than 18 and including 35 years old
Caucasian

Exclusion criteria

Exclusion Criteria:

Metabolic abnormalities such as:
1. Lactose intolerant
2. Diabetes Mellitus
3. Hypertension
4. Hypotension
5. Cardiovascular diseases
6. Asthma and other obstructive pulmonary diseases
7. Elevated fasting blood glucose level

Study design

Phase: Not applicable
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Crossover assignment
Masking: None (open label)
Enrollment: 14 participants (actual)

Study arms

Experimental
low feeding frequency (3x)
Dietary Supplement: low feeding frequency (3x)
Experimental
High feeding frequency (14x)
Dietary Supplement: High feeding frequency (14x)

Interventions

Dietary supplementlow feeding frequency (3x)
3 meals a day
Dietary supplementHigh feeding frequency (14x)
14 meals a day

What researchers measure

Primary outcomes

Glucose and insulin metabolism
Time frame: 24 h

Secondary outcomes

Substrate partitioning and metabolic markers
Time frame: 24 h

Study locations

1 site

University of Maastricht
Maastricht, Limburg 6229 ER, Netherlands

References and documents

Publications

Munsters MJ, Saris WH. Effects of meal frequency on metabolic profiles and substrate partitioning in lean healthy males. PLoS One. 2012;7(6):e38632. doi: 10.1371/journal.pone.0038632. Epub 2012 Jun 13. PubMed 22719910 ↗

Timeline

Tracking since Sep 25, 2026

Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Oct 2009, a primary completion of Mar 2010 and a completion of Jun 2010. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered: Dec 16, 2009
First posted: Dec 17, 2009
Start: Oct 2009
Primary completionActual: Mar 2010
CompletionActual: Jun 2010
Last update: Jul 23, 2010

What these dates mean

Start.: When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.: When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.: When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.: Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.

No changes since tracking began. The registry record was last updated on Jul 23, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01034293
Lead sponsor: Maastricht University Medical Center
Collaborators: Nederlandse Zuivel Organisatie
First posted: Dec 17, 2009
Start date: Oct 2009
Primary completion: Mar 2010
Completion: Jun 2010
Last update: Jul 23, 2010

Study contacts

WHM Saris, Prof. Dr.

principal investigator · Maastricht University

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2010. You cannot join it, but the record below documents what was studied.

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Discussion

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