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WithdrawnNCT01019291Updated Mar 27, 2015

Role of Indoor Pollutants on House Dust Mite Allergic Asthma

An interventional study of Formaldehyde and NO2 (Exposure to indoor pollutants) and Placebo (Exposure to indoor pollutants) in Allergic Asthma and Allergy to House Dust Mite, sponsored by University Hospital, Strasbourg, France. Withdrawn at 1 site in France. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2015-03-27.

Sponsored by University Hospital, Strasbourg, France · Not applicable and Interventional

Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Randomized
Ages
18 Years to 50 Years
Sex
All
01

Study summary

It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.

02

Conditions studied

  • Allergic Asthma
  • Allergy to House Dust Mite

Keywords

  • Indoor pollutants
03

In context

Asthma

3,920 studies on the registry are indexed under Asthma; 506 are open to participants now.

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Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 960 studies on the registry; 336 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • M/F 18-50 years of age
  • History of intermittent HDM allergic asthma-FEV1 > 80%
  • Non smokers or smokers with smoking \< 10 PY

Exclusion criteria

Exclusion criteria:

  • Persistent asthma and FEV1\<80%
  • Allergic to pets and pets at home
05

Study design

Phase
Not applicable
Allocation
Randomized
Masking
Double (Participant, Investigator)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    NO2

    NO2 400 µg/m3

    Other: Formaldehyde and NO2 (Exposure to indoor pollutants)

  • Experimental
    Formaldehyde

    Formaldehyde 100 µg/m3

    Other: Formaldehyde and NO2 (Exposure to indoor pollutants)

  • Experimental
    NO2 + Formaldehyde

    mixture of Formaldehyde and NO2

    Other: Formaldehyde and NO2 (Exposure to indoor pollutants)

  • Placebo comparator
    Placebo

    Other: Placebo (Exposure to indoor pollutants)

Interventions

  • OtherFormaldehyde and NO2 (Exposure to indoor pollutants)

    Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.

  • OtherPlacebo (Exposure to indoor pollutants)

    Exposure to indoor pollutants (placebo) in a randomized way, followed by bronchial challenge test with house dust mite extract.

06

Study locations

1 site
  • Unité de Pneumologie, d'Allergologie et de Pathologie Respiratoire de l'Environnement, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg
    Strasbourg, 67091, France
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 27, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01019291
Lead sponsor
University Hospital, Strasbourg, France
First posted
Nov 25, 2009
Last update
Mar 27, 2015

Study contacts

Frederic DE BLAY, MD
principal investigator · Service de Pneumologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Mar 2015. You cannot join it, but the record below documents what was studied.

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