An interventional study of propofol and sevoflurane in Blood Loss, sponsored by University of Chicago. Completed at 1 site in United States. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-02-14.
Sponsored by University of Chicago · Not applicable, Interventional, and Treatment
The purpose of this study is to compare the blood loss during sinus surgery looking at two different types of anesthesia: either intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane.
3,011 studies on the registry are indexed under Hemorrhage; 466 are open to participants now.
This study's enrollment of 33 is below the median of 100 across 1,990 interventional studies indexed under Hemorrhage.
Browse Hemorrhage studies →University of Chicago is the lead sponsor of 924 studies on the registry; 186 are open to participants now.
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Exclusion Criteria:
Intravenous anesthesia with propofol for endoscopic sinus surgery
Drug: propofol
Inhalation anesthesia with sevoflurane for endoscopic sinus surgery
Drug: sevoflurane
100-200mcg/kg/min by infusion
1-3% of sevoflurane (expired)
Estimated Blood Loss
Estimated blood loss in milliliters per hour is calculated by subtracting the volume of total irrigation used during the case from the total amount of fluid in the suction canister at the end of surgery and dividing by surgical time in hours.
Time frame: from the start of surgery to the end of surgery, up to 6 hours
Anesthesiologist Numeric Rating Scale (ANRS)
The anesthesiologist numeric rating scale is to rate the ease of the anesthesia technique ranging from 0 to 10 (10 is best, 0 is worst).
Time frame: at the end of surgery (up to 6 hours)
Surgeon's Numeric Rating Scale (SNRS)
The surgeon's numeric rating scale(SNRS)is to rate the surgical conditions (mucosal bleeding and visibility) on a scale ranging from 0 to 10, with 0 defined as cadaveric conditions and 10 as severe bleeding requiring constant suction.
Time frame: at the end of surgery (up to 6 hours)
| Milestone | Intravenous Anesthesia | Inhalation Anesthesia |
|---|---|---|
| Started | 18 | 15 |
| Completed | 18 | 15 |
| Not completed | 0 | 0 |
Estimated blood loss in milliliters per hour is calculated by subtracting the volume of total irrigation used during the case from the total amount of fluid in the suction canister at the end of surgery and dividing by surgical time in hours.
| mL/h | Intravenous Anesthesia | Inhalation Anesthesia |
|---|---|---|
| Estimated Blood Loss | 78.5 ± 59.4 | 80.3 ± 70.2 |
The anesthesiologist numeric rating scale is to rate the ease of the anesthesia technique ranging from 0 to 10 (10 is best, 0 is worst).
| units on a scale | Intravenous Anesthesia | Inhalation Anesthesia |
|---|---|---|
| Anesthesiologist Numeric Rating Scale (ANRS) | 7.25 (2 to 10) | 9 (8 to 10) |
The surgeon's numeric rating scale(SNRS)is to rate the surgical conditions (mucosal bleeding and visibility) on a scale ranging from 0 to 10, with 0 defined as cadaveric conditions and 10 as severe bleeding requiring constant suction.
| units on a scale | Intravenous Anesthesia | Inhalation Anesthesia |
|---|---|---|
| Surgeon's Numeric Rating Scale (SNRS) | 6 (5 to 9) | 7.25 (4 to 10) |
Non-serious events are listed at a 1% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Intravenous Anesthesia | — | 0/18 (0%) | 0/18 (0%) |
| Inhalation Anesthesia | — | 0/15 (0%) | 0/15 (0%) |
| Age, Continuous(years) | Intravenous Anesthesia | Inhalation Anesthesia | Total |
|---|---|---|---|
| Mean | 41.3 ± 16.9 | 43.4 ± 16.6 | 42.3 ± 16.5 |
| Sex: Female, Male(Participants) | Intravenous Anesthesia | Inhalation Anesthesia | Total |
|---|---|---|---|
| Female | 9 | 7 | 16 |
| Male | 9 | 8 | 17 |
This study is completed, as verified in Jan 2014. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Propofol · Sevoflurane