A Study of Chicory for Treatment of Osteoarthritis of the Hip or Knee (NCT01010919)

Study summary

Extracts of chicory root have anti-inflammatory properties in vitro and in animal models of arthritis. The primary objective of this investigator-initiated, Phase 1, placebo-controlled, double blind, dose-escalating trial is to determine the safety and tolerability of a proprietary bioactive extract of chicory root in patients with osteoarthritis (OA). Secondary objectives are to assess effects on the signs and symptoms of this disorder. Individuals greater than 50 years of age with OA of the hip or knee will be eligible for trial entry.

Conditions studied

Osteoarthritis

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In context

Osteoarthritis

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Lead sponsor

This is the only study on the registry with Phytomedics Inc. as lead sponsor.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 50 Years and older
Sexes eligible: All

Inclusion criteria

Patients must be 50 years of age or older and may be of either gender.
Patients must have have an imaging-confirmed (radiograph or MRI) diagnosis of OA of the hip or knee.
Patients must not have taken a nonsteroidal anti-inflammatory medication for at least 7 days prior to the baseline visit (a single daily aspirin 325 mg or less is allowed throughout the study).
Patients must be able and willing to give informed consent.

Exclusion criteria

Exclusion Criteria:

Any unstable comorbid medical condition that in the opinion of the investigator could interfere with the ability of the patient to complete the study.
Patients who are unable to ambulate and require a wheelchair due to the severity of the arthritis are excluded. Ambulatory aids such as canes and walkers are acceptable.
Patients requiring continuing therapy with nonsteroidal anti-inflammatory drugs are excluded.
Patients requiring any dose of glucocorticoids within the past 30 days are excluded.

Study design

Phase: Phase 1

Interventions

Dietary supplementChicory root extract

Study locations

No study locations are listed for this record.

References and documents

Publications

Olsen NJ, Branch VK, Jonnala G, Seskar M, Cooper M. Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord. 2010 Jul 9;11:156. doi: 10.1186/1471-2474-11-156. PubMed 20618964 ↗

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Nov 10, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01010919
Lead sponsor: Phytomedics Inc.
Collaborators: University of Texas, Southwestern Medical Center at Dallas
First posted: Nov 10, 2009
Last update: Nov 10, 2009

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2009. You cannot join it, but the record below documents what was studied.

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Discussion

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A Study of Chicory for Treatment of Osteoarthritis of the Hip or Knee