CClinicalTrials.gg
Status unknownNCT00988026MXMIN-001Updated Oct 1, 2009

Safety and Efficacy Comparison of Minocycline Microgranules Versus Lymecycline in the Treatment of Mild to Moderate Acne

A Phase 4 interventional study of Minocycline vs Lymecycline in Mild to Moderate Acne, sponsored by Darier. Status unknown at 1 site in Mexico. Open to participants aged 14 Years to 30 Years. Per ClinicalTrials.gov, last updated 2009-10-01.

Sponsored by Darier · Phase 4, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Sep 2009), so the status shown — last known as Recruiting — may be out of date.
Phase
Phase 4
Study type
Interventional
Enrollment
168
Allocation
Randomized
Ages
14 Years to 30 Years
Sex
All
01

Study summary

This is a clinical trial to compare the benefits and possible adverse events of two antibiotic treatments for mild to moderate acne. It is expected that minocycline microgranules will be more effective than lymecycline with a better adverse events profile.

02

Conditions studied

  • Mild to Moderate Acne

Browse trials for

03

In context

Acne Vulgaris

730 studies on the registry are indexed under Acne Vulgaris; 86 are open to participants now.

This study's planned enrollment of 168 is above the median of 69 across 628 interventional studies indexed under Acne Vulgaris.

Browse Acne Vulgaris studies →

Lead sponsor

This is the only study on the registry with Darier as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
14 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Both gender
  • 14 to 30 years old
  • Mild to moderate acne
  • Face localization
  • At least 20 non-inflammatory lesions OR
  • At least 15 inflammatory lesions OR
  • At least 30 total lesions AND
  • Less than 5 nodular lesions

Exclusion criteria

Exclusion Criteria:

  • Patients younger than 14 or older than 30 years old
  • Less than 20 non-inflammatory lesions OR
  • Less than 15 inflammatory lesions OR
  • Less than 30 total lesions
  • Patients with severe acne
  • More than 5 nodular lesions OR
  • More than 50 inflammatory lesions OR
  • More than 125 total lesions
  • Pregnant women
  • Lactating women
05

Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Care provider, Investigator, Outcomes assessor)
Enrollment
168 participants (estimated)

Study arms

  • Experimental
    Minocycline 100 mg

    Minocycline

    Drug: Minocycline vs Lymecycline

  • Active comparator
    Lymecycline 300 mg

    Group B: Lymecycline

    Drug: Minocycline vs Lymecycline

Interventions

  • DrugMinocycline vs Lymecycline

    Minocycline 100 mg OD per mouth for 8 weeks. Lymecycline 300 mg OD per mouth for 8 weeks.

06

What researchers measure

Primary outcomes

  1. Number of inflammatory and non-inflammatory acne lesions

    Time frame: 8 weeks

Secondary outcomes

  1. Incidence of local and systemic adverse events

    Time frame: 8 weeks

07

Study locations

1 of 1 sites recruiting
  • Servicio de Dermatología. Hospital " Dr. José Eleuterio González" de la Universidad Autónoma de Nuevo León
    Monterrey, Nuevo León 64460, Mexico
    Recruiting
08

References and documents

Publications

  • Ocampo-Candiani J, Velazquez-Arenas LL, de la Fuente-Garcia A, Trevino-Gomezharper C, Berber A. Safety and efficacy comparison of minocycline microgranules vs lymecycline in the treatment of mild to moderate acne: randomized, evaluator-blinded, parallel, and prospective clinical trial for 8 weeks. J Drugs Dermatol. 2014 Jun;13(6):671-6. PubMed 24918556 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 1, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00988026
Lead sponsor
Darier
First posted
Oct 1, 2009
Start date
Jun 2009
Primary completion
Feb 2010 (estimated)
Completion
Apr 2010 (estimated)
Last update
Oct 1, 2009

Study contacts

Luis Leobardo Velázquez-Arenas, MD
Contact
leovel2002@yahoo.com.mx
(5281)83481465
Jorge Ocampo-Candiani, MD
Contact
jocampo2000@yahoo.com.mx
(5281)83481465

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2009. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion