An observational study in Obstetric Labor Complications and Prolonged Pregnancy, sponsored by Université de Sherbrooke. Status unknown at 1 site in Canada. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2015-03-04.
Sponsored by Université de Sherbrooke · Observational
Recent studies show that EET and 20-HETE have important biological effects, particularly in the vascular system. The investigators studied the effect of eicosanoids on the gravid rat uterus. The results suggest that 20-HETE had an tocolytics effect on gravid uterus. In the previous study, we demonstrated that the enzymes of the pathway of EET were present in human uterine tissues. Moreover, the addition of an inhibitor of degradation of EET had an tocolytic effect on the human myometrium, as the exogenous addition of 8.9, 14,15-EET and 20-HETE.
Objectives:
Primary objective: To compare the balance of different metabolic pathways of arachidonic acid (AA) of the pregnant human myometrium in pathological situations (preterm labor, uterine atony, prolonged pregnancy).
Specific objectives: i) To study the effect of derived from the AA on in vitro contractile activity of normal and pathological uterine tissues, and ii) detect and quantify the different sub-products of metabolism of AA in the uterine tissues (myometrium, fetal membranes and placenta).
The management of uterine contraction is in the heart of modern obstetrics year, yet the progress made in other specialties, based on the study of smooth muscle have not yet been transposed in obstetrics. A better understanding of systems for regulating the contraction is important in terms of 1) new physiological knowledge, but it could also be the source of 2) modification of strategies to take care of premature delivery (new Tocolytic), or 3) improving the efficiency of uterine muscle during delivery or 4) for treatment of patients with prolonged pregnancy.
It is a clinical study with a slope fundamental aims to examine the metabolic pathways of AA of human myometrium and their functional roles according to their clinical profile divided into three contractile pathological situations - threat of premature delivery, dynamic dystocia, prolonged pregnancy - and two groups of patients at term: a group before work and group work.
The sampling method. After birth, a biopsy will be perform from the lower segment of the uterus. After caesarean sections of membrane and placenta are collected.
The substances studied during isometric tension tests are part of the three degradation pathways of the AA.
89 studies on the registry are indexed under Obstetric Labor Complications; 25 are open to participants now.
This study's planned enrollment of 130 is below the median of 178 across 26 observational studies indexed under Obstetric Labor Complications.
Browse Obstetric Labor Complications studies →Université de Sherbrooke is the lead sponsor of 289 studies on the registry; 68 are open to participants now.
Counted across the registry records on this site, refreshed daily.
women who will have a c-section at the CHUS
Exclusion Criteria:
Women who will have a c-section at the CHUS
effect of eicosanoids on contractile activity of myometrium of pregnant women with pathological situations
Time frame: during c-section
effect of enzymatic inhibitors on contractile activity of myometrium from pregnant women with pathological situations
Time frame: during c-section
detection of enzymes from the different pathways
Time frame: after c-section
quantification of eicosanoids in different tissues
Time frame: after c-section
This study is status unknown, as verified in Mar 2015. You cannot join it, but the record below documents what was studied.
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Obstetric Labor Complications→
Université de Sherbrooke