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CompletedNCT00906542PRECASTUpdated Feb 19, 2010

Predictors of Early Chest Infection in Acute Ischemic Stroke

An observational study in Acute Ischemic Stroke and Pneumonia, sponsored by University of Rostock. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2010-02-19.

Sponsored by University of Rostock · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
530
Ages
18 Years and older
Sex
All
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Study summary

Pneumonia is a frequent complication of acute stroke and is associated with increased mortality and long-term impairment in the affected subjects. In previous studies, a number of clinical (e.g., dysphagia, severe neurological impairment, mechanical ventilation), radiological (e.g., large infarctions in the territory of middle cerebral artery, insular infarction) and biochemical (e.g., increased serum levels of C-reactive protein, decreased levels of CD4+ T-lymphocytes) findings have been reported as risk factors of stroke-related chest infection. The present study (PRECAST) aims to identify a small set out of these previously described risk factors that can predict stroke-related pneumonia with high sensitivity and specificity.

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Conditions studied

  • Acute Ischemic Stroke
  • Pneumonia

Keywords

  • acute stroke
  • ischemic stroke
  • pneumonia
  • chest infection
  • brain lesion
  • lesion topology
  • dysphagia
  • sympathetic activation
  • immunosuppression
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In context

Infections

6,687 studies on the registry are indexed under Infections; 807 are open to participants now.

This study's enrollment of 530 is above the median of 240 across 2,136 observational studies indexed under Infections.

Browse Infections studies →

Lead sponsor

University of Rostock is the lead sponsor of 46 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Acute ischemic stroke patients admitted to the neurological intensive care unit or stroke unit within 24 hours after stroke onset

Inclusion criteria

  • acute ischemic stroke
  • admission to the neurological intensive care unit or stroke unit within 24 hours after stroke onset
  • clearly assessed brain lesion location

Exclusion criteria

Exclusion Criteria:

  • previous large (non-lacunar) stroke
  • chest infection present already on hospital admission
  • mechanical ventilation already on day 1 or 2 after hospital admission
  • treatment with immunosuppressive drugs
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
530 participants (actual)

Groups and cohorts

  • Acute ischemic stroke patients

    Acute ischemic stroke patients admitted to the neurological intensive care unit or stroke unit within 24 hours after stroke onset in whom ischemic brain lesion was clearly assessed on CT and/or MRI

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What researchers measure

Primary outcomes

  1. diagnosis of chest infection within 7 days after stroke

    Time frame: days 1-7 after stroke

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Study locations

1 site
  • University of Rostock, Department of Neurology
    Rostock, D-18147, Germany
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References and documents

Publications

  • Prass K, Meisel C, Hoflich C, Braun J, Halle E, Wolf T, Ruscher K, Victorov IV, Priller J, Dirnagl U, Volk HD, Meisel A. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med. 2003 Sep 1;198(5):725-36. doi: 10.1084/jem.20021098. Epub 2003 Aug 25. PubMed 12939340 ↗
  • Chamorro A, Amaro S, Vargas M, Obach V, Cervera A, Torres F, Planas AM. Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke. J Neurol Neurosurg Psychiatry. 2006 Nov;77(11):1279-81. doi: 10.1136/jnnp.2006.100800. PubMed 17043295 ↗
  • Chamorro A, Amaro S, Vargas M, Obach V, Cervera A, Gomez-Choco M, Torres F, Planas AM. Catecholamines, infection, and death in acute ischemic stroke. J Neurol Sci. 2007 Jan 15;252(1):29-35. doi: 10.1016/j.jns.2006.10.001. Epub 2006 Nov 28. PubMed 17129587 ↗
  • Walter U, Knoblich R, Steinhagen V, Donat M, Benecke R, Kloth A. Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unit. J Neurol. 2007 Oct;254(10):1323-9. doi: 10.1007/s00415-007-0520-0. Epub 2007 Mar 14. PubMed 17361338 ↗
  • Vogelgesang A, Grunwald U, Langner S, Jack R, Broker BM, Kessler C, Dressel A. Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke. Stroke. 2008 Jan;39(1):237-41. doi: 10.1161/STROKEAHA.107.493635. Epub 2007 Nov 29. PubMed 18048864 ↗
  • Steinhagen V, Grossmann A, Benecke R, Walter U. Swallowing disturbance pattern relates to brain lesion location in acute stroke patients. Stroke. 2009 May;40(5):1903-6. doi: 10.1161/STROKEAHA.108.535468. Epub 2009 Mar 12. PubMed 19286597 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 19, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00906542
Lead sponsor
University of Rostock
First posted
May 21, 2009
Start date
May 2009
Primary completion
Feb 2010
Completion
Feb 2010
Last update
Feb 19, 2010

Study contacts

Uwe Walter, MD
study chair · University of Rostock, Germany

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2010. You cannot join it, but the record below documents what was studied.

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