CClinicalTrials.gg
CompletedNCT00900432Updated Dec 3, 2015

Immune Response in Peripheral Blood of Patients With Colon Cancer

An observational study in Colorectal Cancer, sponsored by University of Arizona. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2015-12-03.

Sponsored by University of Arizona · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
67
Sex
All
01

Study summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in the immune system that may help kill cancer cells.

PURPOSE: This laboratory study is looking at anticancer immune responses in the peripheral blood of patients with colon cancer.

Read the detailed description

OBJECTIVES:

  • Quantify T cells specific for tumor peptides (carcinoembryonic antigen and MUC1) from the peripheral blood of patients with colon cancer.

OUTLINE: This is an open-label study.

Patients undergo blood collection at time of follow-up, surgery, thoracentesis, paracentesis, or leukapheresis (≤ 5 times per year). Blood is analyzed for tumor peptides (carcinoembryonic antigen and MUC1), circulating cytokines, and lymphocyte response by ELISA, ELISPOT, or intracellular flow.

PROJECTED ACCRUAL: A total of 140 patients will be accrued for this study.

02

Conditions studied

  • Colorectal Cancer

Keywords

  • recurrent colon cancer
  • stage I colon cancer
  • stage II colon cancer
  • stage III colon cancer
  • stage IV colon cancer
03

In context

Colorectal Neoplasms

5,599 studies on the registry are indexed under Colorectal Neoplasms; 1,459 are open to participants now.

This study's enrollment of 67 is below the median of 250 across 1,226 observational studies indexed under Colorectal Neoplasms.

Browse Colorectal Neoplasms studies →

Lead sponsor

University of Arizona is the lead sponsor of 466 studies on the registry; 87 are open to participants now.

Of its 47 completed or terminated interventional studies of FDA-regulated products, 29 (62%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

colon cancer

Eligibility criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of colon cancer

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
67 participants (actual)

Interventions

  • Otherimmunoenzyme technique
  • Otherlaboratory biomarker analysis
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What researchers measure

Primary outcomes

  1. Quantitation of T cells specific for tumor peptides (carcinoembryonic antigen and MUC1)

    Time frame: 3 months

07

Study locations

1 site
  • Arizona Cancer Center at University of Arizona Health Sciences Center
    Tucson, Arizona 85724-5024, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 3, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00900432
Lead sponsor
University of Arizona
Collaborators
National Cancer Institute (NCI)
Responsible party
Sponsor
First posted
May 12, 2009
Start date
Jul 2004
Primary completion
Dec 2008
Completion
Dec 2008
Last update
Dec 3, 2015

Study contacts

Michael Demeure, MD
study chair · University of Arizona

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2012. You cannot join it, but the record below documents what was studied.

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