CClinicalTrials.gg
Status unknownNCT00849602Updated Feb 24, 2009

The Effect of Chloroquine in the Treatment of Patients With Dengue

A Phase 1/2 interventional study of Placebo and Chloroquine in Dengue, sponsored by University of Sao Paulo. Status unknown at 1 site in Brazil. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2009-02-24.

Sponsored by University of Sao Paulo · Phase 1/2, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Feb 2009), so the status shown — last known as Active, not recruiting — may be out of date.
Phase
Phase 1/2
Study type
Interventional
Enrollment
132
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The objective of this study was to evaluate the effect of chloroquine in the treatment of patients with dengue.

02

Conditions studied

  • Dengue

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03

In context

Dengue

279 studies on the registry are indexed under Dengue; 45 are open to participants now.

This study's planned enrollment of 132 is close to the median of 123 across 195 interventional studies indexed under Dengue.

Browse Dengue studies →

Lead sponsor

University of Sao Paulo is the lead sponsor of 1,003 studies on the registry; 88 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients suspected of having dengue disease
  • Patients were included in the study if they presented with fever and at least two other symptoms, such as:

    • headache
    • pain behind the eyes
    • muscle and bone or joint pains
    • nausea
    • vomiting
    • rash associated to dengue for less than 72 hours

Exclusion criteria

Exclusion Criteria:

  • Pregnant
  • Younger than 18-years old
  • Either cardiac or neurologic disease
05

Study design

Phase
Phase 1 / Phase 2
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
132 participants (estimated)

Study arms

  • Placebo comparator
    1

    Drug: Placebo

  • Active comparator
    2

    Drug: Chloroquine

Interventions

  • DrugPlacebo

    Placebo bid for three days

  • DrugChloroquine

    Chloroquine bid for three days

06

What researchers measure

Primary outcomes

  1. Duration of the disease

    Time frame: one week

Secondary outcomes

  1. Intensity and days of fever and symptoms

    Time frame: one week

07

Study locations

1 site
  • São Paulo University Medical School at Ribeirão Preto
    Ribeirão Preto, SP 14048.900, Brazil
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 24, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00849602
Lead sponsor
University of Sao Paulo
Collaborators
Fundação de Amparo à Pesquisa do Estado de São Paulo
First posted
Feb 24, 2009
Start date
Feb 2008
Primary completion
May 2008 (estimated)
Completion
Jun 2009 (estimated)
Last update
Feb 24, 2009

Study contacts

Benedito AL Fonseca, PhD
principal investigator · São Paulo University Medical School at Ribeirão Preto

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Feb 2009. You cannot join it, but the record below documents what was studied.

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