A Phase 2 interventional study of modafinil in Schizophrenia, sponsored by Manhattan Psychiatric Center. Withdrawn. Open to participants aged 18 Years to 64 Years. Per ClinicalTrials.gov, last updated 2020-10-14.
Sponsored by Manhattan Psychiatric Center · Phase 2, Interventional, and Treatment
This is an open label 8-week trial of modafinil up to 400 mg daily added to a stable antipsychotic regimen to evaluate the effect modafinil on cognition, sedation, and weight in patients with chronic schizophrenia. We hypothesize that modafinil, a wake-promoting agent, will lead to improved cognition, increased wakefulness, and decreased weight in patients with schizophrenia who are on stable antipsychotic regimens
This study was withdrawn due to no source of funding to implement the study. No participants were enrolled for this study.
3,563 studies on the registry are indexed under Schizophrenia; 491 are open to participants now.
Browse Schizophrenia studies →Manhattan Psychiatric Center is the lead sponsor of 9 studies on the registry; 1 is open to participants now.
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A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
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Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
The human immunodeficiency virus, which weakens the immune system.
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ECG (electrocardiogram)
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Clinically significant
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Study withdrawn due to lack of funds.
Drug: modafinil
Modafinil up to 400 mg daily will be added to a stable antipsychotic regimen
Also known as: Provigil
Cognitive changes as measured by the NIH MATRICS - Consensus Cognitive Battery (MCCB)
Study withdrawn due to lack of funds.
Time frame: 8 weeks
Sedation and weight changes
Study withdrawn due to lack of funds.
Time frame: 8 weeks
No study locations are listed for this record.
The record gives a start of Feb 2008, a primary completion of Jan 2012 and a completion of Jun 2012. It does not say whether these dates are actual or estimated.
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This study is withdrawn, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Modafinil
Manhattan Psychiatric Center