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CompletedNCT00801034Updated Aug 21, 2015

The Effects of Potassium on Physiological and Cardiovascular Variables in Healthy Persons

A Phase 1 interventional study of Calcium and Potassium in Hypertension, sponsored by Erling Bjerregaard Pedersen. Completed at 1 site in Denmark. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-08-21.

Sponsored by Erling Bjerregaard Pedersen · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
25
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
All
01

Study summary

In humans living of fruit and vegetables, hypertension is rarely seen. We wish to study if the development of hypertension has a connection to our intake of potassium. We know that fruit and vegetables contain a lot of potassium and we will simulate this intake by giving healthy subjects potassium as tablets.

02

Conditions studied

  • Hypertension

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Keywords

  • hypertension
  • potassium
  • blood pressure
03

In context

Hypertension

6,687 studies on the registry are indexed under Hypertension; 964 are open to participants now.

This study's enrollment of 25 is below the median of 90 across 4,994 interventional studies indexed under Hypertension.

Browse Hypertension studies →

Lead sponsor

Erling Bjerregaard Pedersen is the lead sponsor of 16 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy
  • age 18-40 years old
  • BMI 18, 5-30
  • non-smoker

Exclusion criteria

Exclusion Criteria:

  • daily use of medicine
  • alcohol or drugs
  • desire to become pregnant
  • not using safe anti-contraceptive
  • abnormal results in the initial testing
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
25 participants (actual)

Study arms

  • Placebo comparator
    1

    Calcium tablets

    Drug: Calcium

  • Active comparator
    2

    Potassium tablets

    Drug: Potassium

Interventions

  • DrugCalcium

    tablets, 1 tablet 2 times per day in 28 days

  • DrugPotassium

    Tablets, 5 tablets 2 times per day for 28 days

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What researchers measure

Primary outcomes

  1. Effect on blood pressure

    Time frame: three months

07

Study locations

1 site
  • Department of medical research
    Holstebro, 7500, Denmark
08

References and documents

Publications

  • Matthesen SK, Larsen T, Vase H, Lauridsen TG, Pedersen EB. Effect of potassium supplementation on renal tubular function, ambulatory blood pressure and pulse wave velocity in healthy humans. Scand J Clin Lab Invest. 2012 Feb;72(1):78-86. doi: 10.3109/00365513.2011.635216. Epub 2011 Dec 12. PubMed 22149452 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 21, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00801034
Lead sponsor
Erling Bjerregaard Pedersen
Responsible party
Erling Bjerregaard Pedersen (professor, chief physician, Regional Hospital Holstebro) — Sponsor-investigator
First posted
Dec 3, 2008
Start date
Nov 2008
Primary completion
Nov 2011
Completion
Nov 2011
Last update
Aug 21, 2015

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2011. You cannot join it, but the record below documents what was studied.

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