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CompletedNCT00798668Updated Sep 24, 2013

The Body's Response to Food Intake in Trained, Older Adults

An interventional study of Liquid Supplements and Solid Supplement in Elderly, sponsored by Purdue University. Completed at 1 site in United States. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-09-24.

Sponsored by Purdue University · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
60 Years and older
Sex
All
01

Study summary

The purpose of this research study is to determine the effects of food supplements and strength training on appetite, the amount of energy expended, and body composition.

02

Conditions studied

  • Elderly

Keywords

  • Endocrine and Gastrointestinal Response to Food
03

In context

Lead sponsor

Purdue University is the lead sponsor of 168 studies on the registry; 23 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

All subjects must meet the following eligibility criteria:

  • Age range: 60 years and older
  • Body mass index between 20-29 kg/m2
  • Weight stable (\< 2 kg weight change within last 6 months)
  • Non-smoking
  • Constant habitual activity patterns within last 3 months
  • Clinically normal blood profiles (specifically, normal liver and kidney function; normal complete blood count (non-anemic); fasting blood glucose \<110 mg/dl)
  • Not taking medications known to influence appetite or metabolism
  • Non-diabetic
  • Confirmation of acceptability of eating the study test foods (solids and fluids)

Trained subjects (Recruiting 36; N-25) must meet the following eligibility criteria:

  • Resistive exercise training (≥ 2 times a week) based on reported physical activity levels (questionnaire)
  • Active fitness level (≥ 2, 30-minute aerobic exercise sessions/week)

Sedentary subjects (Recruiting 36; N-25) must meet the following eligibility criteria:

  • Resistive exercise training (≤ 1 time a week) based on reported physical activity levels (questionnaire)
  • Active fitness level (≤ 2, 30-minute aerobic exercise sessions/week)

Exclusion criteria

Exclusion Criteria:

All subjects will be excluded based on the following exclusionary criteria:

  • Age: \<60 years
  • Body mass index: outside of the 20-29 kg/m2 range
  • Gained or lost > 4.5 kg within the last 6 months
  • Smoker (currently or within the last year)
  • Intermittently been involved in a diet and/or exercise program within the last 3 months
  • Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
  • Taking medications (currently or within the last 3 months) known to influence appetite or metabolism
  • Abnormal heart function (interpreted by a cardiologist) and assessed (for study exclusion) by our study physician, Arthur Rosen, MD
  • Clinically diagnosed as diabetic
  • Study foods are found to be unacceptable for consumption by the subject
  • Clinically diagnosed osteoporosis

Trained subjects will be excluded based on the following exclusionary criteria:

  • Did not perform resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
  • Perform ≤ 1, 30-minute aerobic exercise session/week (currently or within the last 3 months) based on physical activity levels questionnaire)

Sedentary subjects will be excluded based on the following exclusionary criteria:

  • Performed resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
  • Perform > 2, 30-minute aerobic exercise sessions/week (currently or within the last 3 months) based on physical activity levels questionnaire)
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
50 participants (actual)

Study arms

  • Experimental
    1

    participants continue current exercise and take liquid supplement

    Dietary Supplement: Liquid Supplements

  • Experimental
    2

    Participants continue current exercise and take solid supplement

    Dietary Supplement: Solid Supplement

  • Experimental
    3

    Participants continue current sedentary behavior and take liquid supplements

    Dietary Supplement: Liquid Supplements

  • Experimental
    4

    Participants continue current sedentary behavior and take solid supplements

    Dietary Supplement: Solid Supplement

Interventions

  • Dietary supplementLiquid Supplements

    Liquid supplement that provides 12.5% of the subjects total energy requirement.

  • Dietary supplementSolid Supplement

    Solid supplement that provides 12.5% of the subjects total energy requirement.

06

What researchers measure

Primary outcomes

  1. Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in trained and untrained, elderly people.

    Time frame: 6 weeks

Secondary outcomes

  1. Quantify the contribution of selected satiety factors (glucose, insulin, CCK, ghrelin, and GLP-1) and gastrointestinal transit time, to the differential appetitive responses to fluid versus solid foods in trained and untrained, elderly people

    Time frame: 6 weeks

07

Study locations

1 site
  • Purdue University
    West Lafayette, Indiana 47907, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 24, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00798668
Lead sponsor
Purdue University
Responsible party
Wayne Campbell (Professor, Foods and Nutrition, Purdue University) — Principal investigator
First posted
Nov 26, 2008
Start date
Sep 2006
Primary completion
Aug 2007
Completion
May 2008
Last update
Sep 24, 2013
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.

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