An interventional study of erythropoietin and placebo (saline) in Insulin Sensitivity, sponsored by Aarhus University Hospital. Completed at 1 site in Denmark. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-05-29.
Sponsored by Aarhus University Hospital · Not applicable, Interventional, and Basic science
Recently EPO receptors have been found in human muscle tissue, but what is still not known is the physiological role of these receptors. In this study the researchers want to investigate if there is any effect of a acute administration of EPO on insulin resistance and/or substrate metabolism in muscle tissue.
Recently EPO receptors have been found in human muscle tissue, but what is still not known is what the physiological role of these receptors are. It has previously been shown that Growth Hormone mediate insulin resistance. The GH receptor and EPO receptor belong to the same family of cytokine receptors, and thereby share many of the same signalling pathways. In this study we want to investigate if there is a similar effect on insulin resistance and/or substrate metabolism after acute administration of EPO in human muscle tissue. Different signalling pathways are investigated på western blotting, and insulin sensitivity are measured be a hyperinsulinemic euglycemic clamp, and substrate metabolism is measured by the forearm model.
1,960 studies on the registry are indexed under Insulin Resistance; 306 are open to participants now.
This study's planned enrollment of 10 is below the median of 40 across 1,536 interventional studies indexed under Insulin Resistance.
Browse Insulin Resistance studies →Aarhus University Hospital is the lead sponsor of 289 studies on the registry; 79 are open to participants now.
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Exclusion Criteria:
placebo
Drug: placebo (saline)
acute administration of erythropoietin
Drug: erythropoietin
bolus of 400 IU/kg
i.v
Insulin sensitivity
Time frame: 4 and 6 hours post
Substrate metabolism
Time frame: 4 and 6 hours post
This study is completed, as verified in May 2009. You cannot join it, but the record below documents what was studied.
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Aarhus University Hospital