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CompletedNCT00750932Pro-MucoUpdated Feb 27, 2017

Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis

An observational study in Cystic Fibrosis, sponsored by University Hospital, Tours. Completed at 1 site in France. Open to participants aged 6 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-02-27.

Sponsored by University Hospital, Tours · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
52
Ages
6 Years and older
Sex
All
01

Study summary

The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the lung tissue.

The respiratory failure which results from it is one of main causes of the fatal evolution of this pathology but the anti-inflammatory therapies based on the use of antiproteases targeting specifically the soluble elastase did not end, until now, in the hoped results.

The identification of the other noxious targets is a crucial element to give new orientations to the anti-inflammatory strategies based on the administration of antiproteases which remain a promising way.

02

Conditions studied

  • Cystic Fibrosis
03

In context

Cystic Fibrosis

1,581 studies on the registry are indexed under Cystic Fibrosis; 190 are open to participants now.

This study's enrollment of 52 is below the median of 85 across 482 observational studies indexed under Cystic Fibrosis.

Browse Cystic Fibrosis studies →

Lead sponsor

University Hospital, Tours is the lead sponsor of 304 studies on the registry; 78 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
6 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Adults and children with cystic fibrosis

Inclusion criteria

  • Man /woman older than 18 years (for adult and group)
  • Child aged 6 to 18 years (for child group)
  • Suffering from cystic fibrosis in stable condition, ie not having presented thrust acute attack of the broncho-pulmonary or hospitalization for treatment of his illness during the previous 2 weeks

Exclusion criteria

Exclusion Criteria:

  • colonized by Burkholderia cepacia ou Stenotrophomonas maltophilia
  • non smoker (control group)
  • Without history or respiratory respiratory disease known (control group)
  • Antibiotic treatment and / or anti-inflammatory drug (NSAID or corticosteroids) in the 2 weeks prior to the inclusion in the study (control group)
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
52 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • T

    Control

  • M

    Minor with cystic fibrosis

  • A

    Adult with cystic fibrosis

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Study locations

1 site
  • CHRU de Tours
    Tours, 37044, France
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 27, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00750932
Lead sponsor
University Hospital, Tours
Responsible party
Sponsor
First posted
Sep 11, 2008
Start date
Jan 2008
Primary completion
Jan 2012
Completion
Jan 2012
Last update
Feb 27, 2017

Study contacts

Patrice DIOT, PHD
principal investigator · Tours Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.

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