An observational study in Congestive Heart Failure, sponsored by Amsterdam UMC, location VUmc. Status unknown at 1 site in Netherlands. Per ClinicalTrials.gov, last updated 2008-07-16.
Sponsored by Amsterdam UMC, location VUmc · Observational
Evidence exists that oxidative stress is enhanced in congestive heart failure patients resulting in damage to cellular lipids, proteins and DNA. Because of free radical-induced apoptosis of skeletal muscle fibers, oxidative stress is an important contributor to skeletal muscle fatigue and low exercise tolerance of congestive heart failure patients. Enhanced oxidative stress in congestive heart failure can exert negative inotropic effects and can have important effects on the structure and function of the myocardium, and may be implicated in the progression of congestive heart failure. Free radical stress could also impair recruitment and differentiation of circulating endothelial progenitor cells resulting in increased all cause mortality.
Reduced pulmonary clearance of free radical loaded white blood cells and platelets is an important contributor to enhanced oxidative stress in congestive heart failure patients. Failure of pulmonary clearance of free radical loaded white blood cells and platelets probably results from pulmonary congestion which has led to the rationale of the current study. Biventricular pacing for resynchronization therapy in congestive heart failure patients reduces left ventricular filling pressure and pulmonary congestion. Biventricular pacing may therefore augment pulmonary clearance of free radical loaded white blood cells and platelets in congestive heart failure patients.
We conduct a prospective, observational clinical study to investigate the correlation of left ventricular filling pressure, pulmonary clearance of FR loaded circulating white blood cells and platelets and number of endothelial progenitor cells in congestive heart failure (CHF) patients before and after implantation of a biventricular pacemaker for resynchronization therapy.
5,803 studies on the registry are indexed under Heart Failure; 1,222 are open to participants now.
This study's planned enrollment of 20 is below the median of 200 across 1,719 observational studies indexed under Heart Failure.
Browse Heart Failure studies →Amsterdam UMC, location VUmc is the lead sponsor of 305 studies on the registry; 84 are open to participants now.
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Patients admitted to the OLVG hospital for worsening congestive heart failure selected for biventricular pacemaker implantation
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Patient selection
Informed consented participants are recruited among all patients admitted to the OLVG hospital.
Inclusion criteria:
Exclusion criteria:
Informed consented participants are recruited among all patients admitted to the OLVG hospital. Inclusion criteria: * Chronic congestive heart failure patients of all ages selected for biventricular pacemaker implantation for resynchronization therapy * Dyspnoe NYHA class III and IV * Optimal and constant heart failure treatment according to the ESC guidelines Exclusion criteria: * Renal failure (creatinine \>1.70 mg/dl) * Signs of infection or inflammation
The control group consists of ten age-matched volunteers with a normal left ventricular ejection fraction and without signs or symptoms of heart failure.
• Number of (apoptotic) endothelial (progenitor) cells
Time frame: baseline
• Oxidative stress: cytosolic and mitochondrial FR
Time frame: baseline
This study is status unknown, as verified in May 2008. You cannot join it, but the record below documents what was studied.
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Amsterdam UMC, location VUmc →