A Phase 4 interventional study of Simvastatin 40mg and Placebo in Hypertension, sponsored by Hospital de Clinicas de Porto Alegre. Status unknown at 1 site in Brazil. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2009-06-26.
Sponsored by Hospital de Clinicas de Porto Alegre · Phase 4, Interventional, and Treatment
Few trials have investigated the hypotensive effect of the Statins. Most were not specifically aimed at this pleiotropic effect or had methodological problems. The possible hypotensive effect may explain part of the favorable results of the Statins use on cardiovascular prevention independently from its action on the cholesterol profile.
The purpose of this study is to determine the effect of Simvastatin on the blood pressure
This is a randomized double blind parallel clinical trial where hypertensive patients with controlled or uncontrolled blood pressure and without evidence of target-organ damage will be selected. Subjects will receive Simvastatin 40 mg once daily or placebo and a baseline and eight weeks ABPM will performed. The main outcome will be the difference in systolic BP in the 24h-ABPM.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's planned enrollment of 92 is close to the median of 90 across 4,995 interventional studies indexed under Hypertension.
Browse Hypertension studies →Hospital de Clinicas de Porto Alegre is the lead sponsor of 450 studies on the registry; 61 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Simvastatin 40 mg
Drug: Simvastatin 40mg
Drug: Placebo
Simvastatin once daily, orally in the morning period, during eigth weeks
Placebo once daily, orally in the morning period, during eigth weeks
Blood Pressure measured with 24-Ambulatory Blood Pressure Monitoring (24h-ABPM)
Time frame: Eigth weeks
This study is status unknown, as verified in Jun 2009. You cannot join it, but the record below documents what was studied.
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Hospital de Clinicas de Porto Alegre