A First Time in Human Study of GSK586529 in Healthy Volunteers

• Healthy males aged 18-45 years, inclusive.
• Healthy subjects, defined as individuals who are free from clinically significant illness or disease as determined by their (and familial) medical and psychiatric history, physical examination, laboratory studies, and other tests.
• Body weight >/= 50 kg (110 lbs) and BMI within the range 18.5-29.9 kg/m2 inclusive.
• Demonstrates no evidence of active disease, physical or mental impairment.
• Self-administered Beck Depression Inventory II scale total score no greater than 9, and suicide question score of zero.
• Non-smoker (abstinence from smoking for at least 6 months before the start of the study).
• Normal electrocardiogram (subjects must have no clinically significant abnormalities on a 12-lead ECG and a 24 hour Holter ECG).
• Read, comprehend, and write English at a sufficient level to complete study-related materials.

Exclusion Criteria:

• As a result of any of the medical interview, physical examination, evaluation of mental state and psychiatric history or screening investigations the physician responsible considers the subject unfit for the study.
• The subject has a positive pre-study drug/alcohol screen.
• A positive pre-study HIV, Hepatitis B surface antigen or positive Hepatitis C antibody
• The subject has a history of psychiatric illness.
• Any history of suicidal attempts or behavior.
• Abuse of alcohol defined as an average weekly intake of greater than 21 units or an average daily intake of greater than three units..
• Consumption of grapefruit juice or grapefruit within 14 days prior to the first dose of study medication.
• Any subject who is not prepared to eat the standard meals provided by the clinic or is a vegetarian.
• Any history of an endocrine disorder including, but not limited to, diabetes or disorders of the hypothalamus, pituitary, adrenal, or thyroid glands, or gonadal disorder or dysfunction of the reproductive organs.
• Clinically significant abnormal; total and free testosterone, LH, FSH, ACTH or cortisol, or TSH or T4 values at screening/baseline
• LFTs elevated
• Any other clinically significant laboratory abnormality
• The subject has a screening ECG with parameters outside ranges defined in the protocol will also be excluded.
• History of long QT syndrome (personal or family) or other cardiac conduction disorder, or other clinically significant cardiac disease.
• The subject has received an investigational drug or participated in any other research trial within 3 months or 5 half-lives, or twice the duration of the biological effect of any drug(whichever is longer) prior to the first dose of study medication.
• Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John'sWort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and sponsor the medication will not interfere with the study procedures or compromise subject safety.
• History or presence of allergy to the study drug or drugs of this class, or a history of drug or other allergy that, in the opinion of the physician responsible, contraindicates their participation.
• Donation of more than 500 mL blood within the 3 months before dosing.
• An unwillingness of male subjects to abstain from sexual intercourse with pregnant or lactating women from the time of the first dose of study medication until 90 days following administration of the last dose of study medication
• An unwillingness of the male subject to use a condom/spermicide in addition to having their female partner use another form of contraception if the woman could become pregnant from the time of the first dose of study medication until 90 days following administration of the last dose of study medication.
• Current or recent (within one year) gastrointestinal disease; a history of malabsorption, esophageal reflux, peptic ulcer disease, irritable bowel syndrome; frequent (more than once a week) occurrence of heartburn; or any surgical intervention (e.g., cholecysectomy) which would be expected to influence the absorption of drugs.
• Average daily caffeine intake equivalent to > 4 cups of coffee or > 6 cups of tea.
• A semi-supine systolic blood pressure less than 90mmHg or greater than 140mmHg or a semi-supine diastolic blood pressure of less than 60mmHg or greater than 90mmHg; or a radial pulse rate less than 40bpm or more than 90bpm.