An observational study in Gastroesophageal Reflux Disease and Obesity, sponsored by Lotung Poh-Ai Hospital. Completed at 1 site in Taiwan. Open to participants aged 20 Years to 70 Years. Per ClinicalTrials.gov, last updated 2010-10-19.
Sponsored by Lotung Poh-Ai Hospital · Observational
Gastroesophageal reflux disease (GERD) is a common and important disorder. Previous studies have demonstrated the association of obesity with GERD, and now obesity is regarded as a risk factor for GERD. Moreover, body mass index (BMI), an indicator of general obesity, correlates with severity of symptoms and degree of erosive esophagitis. Waist circumference, an indicator of abdominal obesity, has stronger correlation with intra-abdominal pressure and low-grade inflammatory state when compared with BMI. Nevertheless the association of waist circumference with severity of GERD has not been studied.
The primary aim of this study is to compare BMI with waist circumference for their independent association with severity of GERD. The secondary aim is to evaluate independent risk factors of severity of GERD.
This is a cross-section observational study. Outpatients presenting with acid reflux or heart burn are interviewed with standardized questionnaire to quantify severity of symptoms. The eligible patients undergo upper endoscopy to diagnose erosive esophagitis and further classify the degree of erosions according to Los-Angels classification. Enrolled patients receive anthropometric measurements to record body weight, body height and waist circumference on the day of enrollment.
Two outcomes are studied: the severity of GERD symptoms and the Los-Angels Classification of erosive esophagitis.
1,067 studies on the registry are indexed under Gastroesophageal Reflux; 188 are open to participants now.
This study's planned enrollment of 500 is above the median of 180 across 298 observational studies indexed under Gastroesophageal Reflux.
Browse Gastroesophageal Reflux studies →Lotung Poh-Ai Hospital is the lead sponsor of 10 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Outpatients at a general hospital with 1000 beds in north-eastern Taiwan
Exclusion Criteria:
patients with typical gastro-reflux symptoms but no erosions were discernible on upper gastrointestinal endoscopy
Other: Anthropometric measurements
Patients with both typical gastroesophageal reflux symptoms and characteristic flam-like erosions as demonstrated on upper gastrointestinal endoscopy
Other: Anthropometric measurements
Patients report no typical reflux symptoms but fulfill diagnostic criteria of functional dyspepsia, whose upper gastrointestinal endoscopy are negative.
Other: Anthropometric measurements
All patients undergo anthropometric measurements to record body weight, body height and waist circumference on the day of enrollment
the degree fo erosive esophagitis according to Los-Angels classification
Time frame: on the day of endoscopy examination
gastro-reflux severity score as evaluated by standardized questionnaire
Time frame: at enrollment (before upper GI endoscopy)
This study is completed, as verified in Oct 2010. You cannot join it, but the record below documents what was studied.
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Lotung Poh-Ai Hospital