An observational study in Familial Mediterranean Fever, sponsored by Sheba Medical Center. Status unknown at 1 site in Israel. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-04-14.
Sponsored by Sheba Medical Center · Observational
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Familial Mediterranean fever (FMF) is an inherited disorder of unknown etiology, characterized by recurrent episodes of fever, peritonitis and/or pleuritis.
Fever is the cardinal manifestation of FMF and is present in most attacks accompanied by abdominal pain.
Another clinical manifestation in patients with FMF is exertional muscle pain, usually in the thigh, which appears even after minor exercise or physical activity in young patients with generally good health (other than FMF) and in good physical condition. Some patients also complain of ankle edema after relatively minor physical activity, which subsides after a night rest. Although these manifestations are quite common in FMF patients and form part of the minor criteria for the diagnosis, the etiopathogenesis has not been examined.
The purpose of the suggested study is to evaluate and characterize the anatomical and biochemical changes in the muscles of the thigh and in the ankle triggered by physical activity in FMF patients complaining of exertional lower leg myalgias and edema after minor physical exercise.
61 studies on the registry are indexed under Familial Mediterranean Fever; 27 are open to participants now.
This study's planned enrollment of 20 is below the median of 89 across 30 observational studies indexed under Familial Mediterranean Fever.
Browse Familial Mediterranean Fever studies →Sheba Medical Center is the lead sponsor of 678 studies on the registry; 63 are open to participants now.
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Patients with FMF, fulfilling the Tel Hashomer criteria for the diagnosis of FMF, suffering from episodes of exertional leg pain and or exertional ankle edema, 18-45 years old, on a stable (≥ 2 weeks) dose of oral colchicine therapy, Non-smokers
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* 1.Fulfilling the Tel Hashomer criteria for the diagnosis of FMF \[5\]. * 2.Suffering from episodes of exertional leg pain and or exertional ankle edema * 3.18-45 years old * 4.On a stable (≥ 2 weeks) dose of oral colchicine therapy * 5.Non-smokers
Control group * 1.Healthy subjects * 2.18-45 years old * 3.Non-smokers
change in spectroscopic appearance of muscle after exertion of muscle thigh
Time frame: 1 hour
change in muscle intensity signal after exertion
Time frame: 1 hour
change in joint effusion status after exertion
Time frame: 1 hour
This study is status unknown, as verified in Apr 2008. You cannot join it, but the record below documents what was studied.
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