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CompletedNCT00647764Updated May 17, 2012

Safety Study Of SNX-5422 To Treat Solid Tumor Cancers And Lymphomas

A Phase 1 interventional study of SNX-5422 Mesylate Hsp90 inhibitor in Solid Tumor Malignancy, Lymphoid Malignancy (Lymphoma and CLL) and Leukemia, sponsored by Esanex Inc.. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-05-17.

Sponsored by Esanex Inc. · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
32
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

Hsp90 is a chemical in the body that is involved in promotion of cancer. SNX-5422 is an experimental drug that blocks Hsp90. It is being evaluated for safety and efficacy in patients with cancer.

02

Conditions studied

  • Solid Tumor Malignancy
  • Lymphoid Malignancy (Lymphoma and CLL)
  • Leukemia
  • Lymphoma
03

In context

Lymphoma

5,578 studies on the registry are indexed under Lymphoma; 825 are open to participants now.

This study's enrollment of 32 is below the median of 40 across 4,508 interventional studies indexed under Lymphoma.

Browse Lymphoma studies →

Lead sponsor

Esanex Inc. is the lead sponsor of 12 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Solid tumors or lymphoid malignancies refractory to standard therapy
  • measurable disease
  • recovery to Grade \< 1 toxicity due to prior adverse event or chemotherapy
  • no chemotherapy within 4 weeks of entering study
  • Age > 18 years
  • Karnofsy >= 60%
  • Life expectancy > 3 months
  • normal or adequate organ and marrow function

Exclusion criteria

Exclusion Criteria:

  • receiving other investigational agents
  • brain metastases
  • uncontrolled medical illness
  • HIV+ receiving combination antiretroviral therapy
  • significant GI disease
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
32 participants (actual)

Study arms

  • Experimental
    Single Arm

    Drug: SNX-5422 Mesylate Hsp90 inhibitor

Interventions

  • DrugSNX-5422 Mesylate Hsp90 inhibitor

    dose escalated, tablets twice a week; undetermined duration until disease progression

06

What researchers measure

Primary outcomes

  1. MTD, safety and toxicity

    Time frame: continuous

Secondary outcomes

  1. pharmacokinetic profile of SNX-5422

    Time frame: first cycle

  2. tumor response measured by X-rays or scans

    Time frame: after every 2 cycles

07

Study locations

1 site
  • Pfizer Investigational Site
    Bethesda, Maryland 20892, United States
08

References and documents

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 17, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00647764
Lead sponsor
Esanex Inc.
Collaborators
National Cancer Institute (NCI)
First posted
Apr 1, 2008
Start date
Mar 2008
Primary completion
Sep 2010
Completion
Sep 2010
Last update
May 17, 2012

Study contacts

Pfizer CT.gov Call Center
study director · Pfizer

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2012. You cannot join it, but the record below documents what was studied.

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